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MRI在宫颈癌患者治疗分层中作用的最新进展

An Update on the Role of MRI in Treatment Stratification of Patients with Cervical Cancer.

作者信息

Shakur Amreen, Lee Janice Yu Ji, Freeman Sue

机构信息

Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.

出版信息

Cancers (Basel). 2023 Oct 23;15(20):5105. doi: 10.3390/cancers15205105.

Abstract

Cervical cancer is the fourth most common cancer in women worldwide and the most common gynaecological malignancy. The FIGO staging system is the most commonly utilised classification system for cervical cancer worldwide. Prior to the most recent update in the FIGO staging in 2018, the staging was dependent upon clinical assessment alone. Concordance between the surgical and clinical FIGO staging decreases rapidly as the tumour becomes more advanced. MRI now plays a central role in patients diagnosed with cervical cancer and enables accurate staging, which is essential to determining the most appropriate treatment. MRI is the best imaging option for the assessment of tumour size, location, and parametrial and sidewall invasion. Notably, the presence of parametrial invasion precludes surgical options, and the patient will be triaged to chemoradiotherapy. As imaging is intrinsic to the new 2018 FIGO staging system, nodal metastases have been included within the classification as stage IIIC disease. The presence of lymph node metastases within the pelvis or abdomen is associated with a poorer prognosis, which previously could not be included in the staging classification as these could not be reliably detected on clinical examination. MRI findings corresponding to the 2018 revised FIGO staging of cervical cancers and their impact on treatment selection will be described.

摘要

宫颈癌是全球女性中第四大常见癌症,也是最常见的妇科恶性肿瘤。国际妇产科联盟(FIGO)分期系统是全球最常用的宫颈癌分类系统。在2018年FIGO分期的最新更新之前,分期仅依赖于临床评估。随着肿瘤进展,手术分期与临床FIGO分期之间的一致性迅速降低。MRI现在在宫颈癌诊断患者中发挥着核心作用,能够进行准确分期,这对于确定最合适的治疗方法至关重要。MRI是评估肿瘤大小、位置、宫旁组织和侧壁侵犯的最佳影像学选择。值得注意的是,宫旁组织侵犯的存在排除了手术选择,患者将接受放化疗。由于影像学是新的2018年FIGO分期系统的内在组成部分,区域淋巴结转移已被纳入分期分类为IIIC期疾病。盆腔或腹部淋巴结转移的存在与较差的预后相关,以前这些情况无法纳入分期分类,因为在临床检查中无法可靠检测到。本文将描述与2018年修订的FIGO宫颈癌分期相对应的MRI表现及其对治疗选择的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6f7/10605640/3f1cf4b1825d/cancers-15-05105-g001.jpg

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