Kędzierska Magdalena, Bańkosz Magdalena, Sala Katarzyna, Dudzik Julia, Potemski Piotr, Tyliszczak Bożena
Department of Chemotherapy, Medical University of Lodz, Copernicus Memorial Hospital of Lodz, 90-549 Lodz, Poland.
Department of Materials Engineering, Faculty of Materials Engineering and Physics, Cracow University of Technology, 37 Jana Pawła II Av., 31-864 Krakow, Poland.
Molecules. 2023 Oct 11;28(20):7035. doi: 10.3390/molecules28207035.
The use of natural ingredients in recent years has been of great importance in many industries and medicine. In biomedical applications, hydrogel materials also play a significant role. In view of this, the aim of this study was to synthesize and characterize hydrogel materials enriched with broadleaf linden hydrolate. An important aspect was to carry out a series of syntheses with varying types and amounts of crosslinking agents so as to test the possibility of synthesizing materials with controlled properties. The obtained hydrogels were subjected to detailed physicochemical analysis. The results of the tests confirmed the relationship between the selected properties and the type of crosslinking agent used. A crosslinking agent with a lower molar mass (575 g/mol) results in a material with a compact and strongly crosslinked structure, which is characterized by high surface roughness. The use of a crosslinking agent with a molecular weight of 700 g/mol resulted in a material with a looser-packed polymer network capable of absorbing larger amounts of liquids. The work also proved that regardless of the type of crosslinking agent used, the addition of linden hydrolate provides antioxidant properties, which is particularly important in view of the target biomedical application of such materials.
近年来,天然成分在许多行业和医学领域都具有重要意义。在生物医学应用中,水凝胶材料也发挥着重要作用。鉴于此,本研究的目的是合成并表征富含阔叶椴树水解物的水凝胶材料。一个重要方面是使用不同类型和数量的交联剂进行一系列合成,以测试合成具有可控性能材料的可能性。对所得水凝胶进行了详细的物理化学分析。测试结果证实了所选性能与所用交联剂类型之间的关系。摩尔质量较低(575 g/mol)的交联剂会产生具有紧密且高度交联结构的材料,其特征在于高表面粗糙度。使用分子量为700 g/mol的交联剂会产生具有较疏松堆积聚合物网络的材料,该材料能够吸收大量液体。这项工作还证明,无论使用何种类型的交联剂,添加椴树水解物都能提供抗氧化性能,鉴于此类材料的目标生物医学应用,这一点尤为重要。