School of Pharmacy, Shenyang Medical College, Shenyang 110034, China.
Molecules. 2023 Oct 12;28(20):7053. doi: 10.3390/molecules28207053.
A rapid and sensitive method that combined ultra-high-performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry (UHPLC-FT-ICR-MS) was used to identify the chemical constituents in Lanqin oral liquid. On the basis of UHPLC-FT-ICR-MS analysis, systematic characterization of the chemical profile of Lanqin oral liquid was carried out, and a total of 441 compounds were identified or tentatively characterized including alkaloids, flavonoids, terpenoids, organic acids, phenylpropanoids, and other types. The results provide a reference for improving quality control, contribute to establishing higher quality standards, provide a scientific basis for further research on the pharmacodynamic material basis, and help illustrate the relationship between the complicated constituents and therapeutic effects of Lanqin oral liquid.
采用超高效液相色谱结合傅里叶变换离子回旋共振质谱（UHPLC-FT-ICR-MS）的快速灵敏方法，鉴定蓝芩口服液中的化学成分。基于 UHPLC-FT-ICR-MS 分析，对蓝芩口服液的化学成分特征进行了系统表征，共鉴定或推测出 441 种化合物，包括生物碱、黄酮类、萜类、有机酸、苯丙素类等类型。研究结果为提高质量控制提供了参考，有助于建立更高的质量标准，为进一步研究其药效物质基础提供了科学依据，并有助于阐明蓝芩口服液复杂成分与疗效之间的关系。
