[Zr]Zr-奥昔宁标记间充质基质细胞在实验动物局部放射损伤中的分布。
Biodistribution of Mesenchymal Stromal Cells Labeled with [Zr]Zr-Oxine in Local Radiation Injuries in Laboratory Animals.
机构信息
State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, 123182 Moscow, Russia.
Institute of Biomedical Chemistry, Biobanking Group, 119121 Moscow, Russia.
出版信息
Molecules. 2023 Oct 19;28(20):7169. doi: 10.3390/molecules28207169.
BACKGROUND
Tracking the migration pathways of living cells after their introduction into a patient's body is a topical issue in the field of cell therapy. Questions related to studying the possibility of long-term intravital biodistribution of mesenchymal stromal cells in the body currently remain open.
METHODS
Forty-nine laboratory animals were used in the study. Modeling of local radiation injuries was carried out, and the dynamics of the distribution of mesenchymal stromal cells labeled with [Zr]Zr-oxine in the rat body were studied.
RESULTS
the obtained results of the labelled cell distribution allow us to assume that this procedure could be useful for visualization of local radiation injury using positron emission tomography. However, further research is needed to confirm this assumption.
CONCLUSIONS
intravenous injection leads to the initial accumulation of cells in the lungs and their subsequent redistribution to the liver, spleen, and kidneys. When locally injected into tissues, mesenchymal stromal cells are not distributed systemically in significant quantities.
背景
追踪活细胞在被引入患者体内后的迁移途径是细胞治疗领域的一个热门问题。目前，与研究间充质基质细胞在体内长期活体生物分布的可能性相关的问题仍然没有答案。
方法
本研究使用了 49 只实验动物。进行了局部放射损伤建模，并研究了标记有[Zr]Zr-oxine 的间充质基质细胞在大鼠体内的分布动力学。
结果
标记细胞分布的结果使我们假设，该方法可用于正电子发射断层扫描术对局部放射损伤的可视化。但是，需要进一步的研究来证实这一假设。
结论
静脉注射会导致细胞最初在肺部聚集，随后重新分布到肝脏、脾脏和肾脏。当局部注射到组织中时，间充质基质细胞不会在体内以大量的方式系统分布。
Zotero 插件