全基因组重测序技术对大足黑山羊繁殖性状的全基因组关联研究。
Genome-Wide Association Study of the Reproductive Traits of the Dazu Black Goat () Using Whole-Genome Resequencing.
机构信息
College of Animal Science and Technology, Southwest University, Chongqing 400715, China.
Chongqing Key Laboratory of Herbivore Science, Chongqing 400715, China.
出版信息
Genes (Basel). 2023 Oct 19;14(10):1960. doi: 10.3390/genes14101960.
Reproductive traits are the basic economic traits of goats and important indicators in goat breeding. In this study, Dazu black goats (DBGs; n = 150), an important Chinese local goat breed with excellent reproductive performance, were used to screen for important variation loci and genes of reproductive traits. Through genome-wide association studies (GWAS), 18 SNPs were found to be associated with kidding traits (average litter size, average litter size in the first three parity, and average litter size in the first six parity), and 10 SNPs were associated with udder traits (udder depth, teat diameter, teat length, and supernumerary teat). After gene annotation of the associated SNPs and in combination with relevant references, the candidate genes, namely , , , , , , , , and , were associated with udder traits, while the , , , , , and genes were associated with litter size. These SNPs and candidate genes can provide useful biological information for improvement of the reproductive traits of goats.
繁殖性状是山羊的基本经济性状，也是山羊育种的重要指标。本研究以繁殖性能优良的中国地方山羊品种——大足黑山羊（DBG；n=150）为研究对象，对其繁殖性状的重要变异位点和基因进行筛选。通过全基因组关联研究（GWAS），发现了 18 个与产羔性状（平均产羔数、前 3 胎平均产羔数、前 6 胎平均产羔数）相关的 SNP，以及 10 个与乳房性状（乳房深度、乳头直径、乳头长度、副乳头）相关的 SNP。对相关 SNP 进行基因注释，并结合相关参考文献，鉴定候选基因，其中， 、 、 、 、 、 、 、 和 与乳房性状相关， 、 、 、 、 、 和 与产羔数相关。这些 SNP 和候选基因可为山羊繁殖性状的改良提供有价值的生物学信息。
Zotero 插件