Vata Dan, Tarcau Bogdan Marian, Popescu Ioana Adriana, Halip Ioana Alina, Patrascu Adriana Ionela, Gheuca Solovastru Dragos-Florin, Mocanu Madalina, Chiriac Petronela Cristina, Gheuca Solovastru Laura
Department of Dermatology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Dermatology Clinic, "St. Spiridon" County Emergency Clinical Hospital, 700111 Iasi, Romania.
Life (Basel). 2023 Sep 22;13(10):1947. doi: 10.3390/life13101947.
Psoriasis is a chronic inflammatory skin condition, with genetic, epigenetic, environmental, and lifestyle factors contributing to its onset and recurrence. Severe psoriasis has a great impact on quality of life, which is similar to that of insulin-dependent diabetes, depression, and ischemic heart disease, but with a lower mortality. There is an overlap between the rising incidences of autoimmune diseases and obesity. In recent years, research has shown that there is an association between psoriasis and obesity. Psoriasis is linked to obesity in a two-way manner, as each can precipitate the development of the other. Several adipose tissue-secreted adipokines were shown to be elevated in obese psoriasis patients, exhibiting similar mechanisms of action to those underlying the pathogenesis of psoriasis. Excess body weight can influence not only the treatment response in psoriasis, but also the adverse events, leading to decreased patient compliance. Specific human microbiome patterns have been identified for obesity and psoriasis and could represent a future therapeutic target in selected individuals.
银屑病是一种慢性炎症性皮肤病，其发病和复发受遗传、表观遗传、环境及生活方式等因素影响。重度银屑病对生活质量有很大影响，与胰岛素依赖型糖尿病、抑郁症及缺血性心脏病类似，但死亡率较低。自身免疫性疾病和肥胖症的发病率呈上升趋势，二者存在重叠。近年来，研究表明银屑病与肥胖症之间存在关联。银屑病与肥胖症相互关联，二者可相互诱发。肥胖的银屑病患者体内，几种脂肪组织分泌的脂肪因子水平升高，其作用机制与银屑病发病机制相似。体重超标不仅会影响银屑病的治疗反应，还会导致不良事件增加，进而降低患者的依从性。已确定肥胖症和银屑病有特定的人类微生物组模式，这可能成为特定个体未来的治疗靶点。
