Department of Psychiatry, First Faculty of Medicine, Charles University and General Teaching Hospital, Prague , Czech Republic.
Department of Psychiatry, First Faculty of Medicine, Charles University and General Teaching Hospital, Prague, Czech Republic.
Med Sci Monit. 2023 Oct 28;29:e941079. doi: 10.12659/MSM.941079.
There is a growing body of research on SARS-CoV-2 (PASC), previously known as the post-COVID syndrome, a chronic condition characterized by symptoms that persist after SARS-CoV-2 infection. Among these symptoms, feelings of physical exhaustion and prolonged fatigue are particularly prevalent and can significantly impact patients' quality of life. These symptoms are associated with reduced overall physical capacity, decreased daily physical activity, malaise after intense training, and intolerance to physical activity (IFA). IFA, described as a reduced ability to perform physical activities typical for the patient's age, can often lead to a sedentary lifestyle. Prolonged physical inactivity can cause deterioration in the overall physical condition and disrupt mitochondrial function, triggering a vicious cycle of gradual symptom worsening. The underlying causes of PASC remain unclear; however, several biochemical mechanisms have been discussed to explain the body's energy depletion, and a multidisciplinary approach that combines physical and cognitive rehabilitation and lifestyle interventions such as exercise and diet modifications has been suggested to improve the overall health and well-being of PASC patients. This critical review aims to review the existing research on the possible causes and links among chronic fatigue, reduced physical activity, and exercise intolerance in patients with PASC. Further research into the underlying causes and treatment of PASC and the importance of developing individualized treatment is needed to address each patient's unique health requirements.
目前有越来越多的研究关注 SARS-CoV-2（以前称为新冠后综合征），这是一种由 SARS-CoV-2 感染后持续存在的症状所定义的慢性疾病。在这些症状中，身体疲惫和长期疲劳感尤为普遍，并会显著影响患者的生活质量。这些症状与整体身体能力下降、日常体力活动减少、剧烈运动后不适以及体力活动不耐受（IFA）有关。IFA 被描述为患者无法完成与其年龄相符的典型体力活动的能力，往往会导致久坐的生活方式。长时间的体力不活动会导致整体身体状况恶化，并破坏线粒体功能，引发症状逐渐恶化的恶性循环。PASC 的根本原因尚不清楚；然而，已经讨论了几种生化机制来解释身体的能量消耗，并且已经提出了一种多学科方法，将身体和认知康复以及生活方式干预（如运动和饮食改变）相结合，以改善 PASC 患者的整体健康和幸福感。这篇关键性综述旨在回顾关于慢性疲劳、体力活动减少和 PASC 患者运动不耐受之间可能存在的因果关系的现有研究。需要进一步研究 PASC 的根本原因和治疗方法，以及制定个体化治疗方案的重要性，以满足每位患者的独特健康需求。
