Undergraduate Program, Faculty of Dentistry, Universitas Indonesia, Jl. Salemba Raya No. 4, 10430, Jakarta Pusat, Indonesia.
Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jl. Salemba Raya No. 4, 10430, Jakarta Pusat, Indonesia.
BMC Oral Health. 2023 Oct 29;23(1):819. doi: 10.1186/s12903-023-03241-2.
Periodontal pockets are characteristic of periodontitis. Scaling and root planing is the gold standard for periodontitis treatment. Additional local antimicrobials are recommended in patients with a probing depth of ≥ 5 mm. This study aims to determine the effectiveness of chlorhexidine compared to other local antimicrobials in periodontitis. Searches were conducted using the Preferred Reporting Items for Systematic Reviews and Meta Analysis (PRISMA) guidelines. Meta-analysis was performed on studies that met inclusion criteria after risk of bias assessment. Meta-analysis between chlorhexidine chips and other antimicrobials showed a mean difference in probing depth after one month of 0.58 mm (p < 0.00001) whereas after three months the mean difference in probing depth was 0.50 mm (p = 0.001), index plaque 0.01 (p = 0.94) and gingival index - 0.11 mm (p = 0.02). Between chlorhexidine gel and other antimicrobials showed a mean difference in probing depth of 0.40 mm (p = 0.30), plaque index of 0.20 mm (p = 0.0008) and gingival index of -0.04 mm (p = 0.83) after one month. Chlorhexidine chips were more effective on the gingival index than other antimicrobials after three months. The other antimicrobials were more effective than chlorhexidine chips on probing depth after one and three months, and than chlorhexidine gels on plaque index after one month.
牙周袋是牙周炎的特征。牙周炎的治疗金标准是洁治和根面平整。对于探诊深度≥5mm 的患者，建议使用局部抗菌药物。本研究旨在确定与其他局部抗菌药物相比，洗必泰在牙周炎治疗中的有效性。检索采用系统评价和荟萃分析的首选报告项目（PRISMA）指南进行。在进行偏倚风险评估后，对符合纳入标准的研究进行荟萃分析。在对使用洗必泰牙片和其他抗菌药物的研究进行荟萃分析后发现，一个月时，探诊深度的平均差值为 0.58mm（p<0.00001），三个月时，探诊深度的平均差值为 0.50mm（p=0.001），菌斑指数为 0.01（p=0.94），牙龈指数为-0.11mm（p=0.02）。在使用洗必泰凝胶和其他抗菌药物的研究中，一个月时，探诊深度的平均差值为 0.40mm（p=0.30），菌斑指数的平均差值为 0.20mm（p=0.0008），牙龈指数的平均差值为-0.04mm（p=0.83）。三个月时，洗必泰牙片在牙龈指数方面比其他抗菌药物更有效。在一个月和三个月时，其他抗菌药物在探诊深度方面比洗必泰牙片更有效，在一个月时，比洗必泰凝胶在菌斑指数方面更有效。
