Kardas Przemyslaw, Aarnio Emma, Agh Tamas, van Boven Job F M, Dima Alexandra Lelia, Ghiciuc Cristina Mihaela, Kamberi Fatjona, Petrova Guenka Ivanova, Nabergoj Makovec Urska, Trečiokienė Indrė
Department of Family Medicine, Medical University of Lodz, Lodz, Poland.
School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland.
Front Pharmacol. 2023 Oct 13;14:1254291. doi: 10.3389/fphar.2023.1254291. eCollection 2023.
Medication non-adherence negatively affects the effectiveness of evidence-based therapies and sustainability of healthcare systems. Lack of agreed terminology of medication adherence enabling and supporting activities leads to underuse of the available tools. The ENABLE COST Action was aimed at proposing a new terminology for these activities in order to help both scientific research and its clinical application. Initial discussions within the ENABLE Working Groups allowed for the conceptualization of four interlinked terms related to adherence, i.e., "medication adherence technology", "medication adherence enhancing intervention", "best practice" and "reimbursement". The iterative process of internal discussion was structured around two dedicated international workshops. Moreover, extensive stakeholder consultations have been organised, including an interactive online survey used to assess the level of agreement with, and the clarity of relevant terms and definitions proposed. Detailed analysis of the results of this process allowed for fine-tuning of the items, and finally, for proposing the final set of definitions. Across all the three phases of this process, the definitions were substantially modified to better reflect the concepts, simplify the language, and assure completeness and cohesiveness of terminology. Feedback obtained from the stakeholders helped this process and confirmed that the final terms and definitions were well received by the experts active in the field of medication adherence. Covering the gap in the existing terminology, this work proposes a cohesive set of terms and definitions applicable to medication adherence enabling and supporting activities. Promoting evidence-based approach to this field, this terminology may help research, clinical practice and policy.
药物治疗依从性不佳会对循证治疗的有效性和医疗保健系统的可持续性产生负面影响。由于缺乏关于促进和支持药物治疗依从性活动的统一术语，导致现有工具未得到充分利用。ENABLE成本行动旨在为这些活动提出新的术语，以帮助科学研究及其临床应用。ENABLE工作组内部的初步讨论促成了与依从性相关的四个相互关联的术语的概念化，即“药物治疗依从性技术”、“增强药物治疗依从性干预”、“最佳实践”和“报销”。内部讨论的迭代过程围绕两次专门的国际研讨会展开。此外，还组织了广泛的利益相关者协商，包括一项交互式在线调查，用于评估对所提出的相关术语和定义的认同程度及清晰度。对这一过程结果的详细分析使得各项内容得以微调，最终提出了最终的定义集。在这一过程的所有三个阶段，定义都经过了大幅修改，以更好地反映概念、简化语言，并确保术语的完整性和连贯性。从利益相关者那里获得的反馈推动了这一过程，并证实最终的术语和定义受到了药物治疗依从性领域活跃专家的好评。这项工作填补了现有术语的空白，提出了一套适用于促进和支持药物治疗依从性活动的连贯术语和定义。该术语促进了该领域的循证方法，可能有助于研究、临床实践和政策制定。
