University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia
Deep Digital Phenotyping Research Unit, Department of Precision Health, Luxembourg Institute of Health, Strassen, Luxembourg.
BMJ Open. 2022 Apr 22;12(4):e059674. doi: 10.1136/bmjopen-2021-059674.
An online interactive repository of available medication adherence technologies may facilitate their selection and adoption by different stakeholders. Developing a repository is among the main objectives of the European Network to Advance Best practices and technoLogy on medication adherencE (ENABLE) COST Action (CA19132). However, meeting the needs of diverse stakeholders requires careful consideration of the repository structure.
A real-time online Delphi study by stakeholders from 39 countries with research, practice, policy, patient representation and technology development backgrounds will be conducted. Eleven ENABLE members from 9 European countries formed an interdisciplinary steering committee to develop the repository structure, prepare study protocol and perform it. Definitions of medication adherence technologies and their attributes were developed iteratively through literature review, discussions within the steering committee and ENABLE Action members, following ontology development recommendations. Three domains ( and )) branching in 13 attribute groups are proposed: . Stakeholders will evaluate the proposed definition and attributes' relevance, clarity and completeness and have multiple opportunities to reconsider their evaluations based on aggregated feedback in real-time. Data collection will stop when the predetermined response rate will be achieved. We will quantify agreement and perform analyses of process indicators on the whole sample and per stakeholder group.
Ethical approval for the COST ENABLE activities was granted by the Malaga Regional Research Ethics Committee. The Delphi protocol was considered compliant regarding data protection and security by the Data Protection Officer from University of Basel. Findings from the Delphi study will form the basis for the ENABLE repository structure and related activities.
一个在线互动的药物依从性技术资源库可以促进不同利益相关者对其进行选择和采用。建立一个资源库是推进药物依从性最佳实践和技术的欧洲网络（ENABLE）合作行动（CA19132）的主要目标之一。然而，要满足不同利益相关者的需求，就需要仔细考虑资源库的结构。
通过来自 39 个国家的研究、实践、政策、患者代表和技术开发背景的利益相关者进行实时在线 Delphi 研究。来自 9 个欧洲国家的 11 名 ENABLE 成员组成了一个跨学科指导委员会，负责开发资源库结构、准备研究方案并进行研究。通过文献回顾、指导委员会和 ENABLE 行动成员内部讨论，以及遵循本体开发建议，反复制定药物依从性技术及其属性的定义。提出了三个领域（、和），分为 13 个属性组：。利益相关者将评估拟议的定义和属性的相关性、清晰度和完整性，并根据实时汇总反馈多次有机会重新考虑他们的评估。当达到预定的回复率时，数据收集将停止。我们将对整个样本和每个利益相关者群体进行一致性和过程指标分析。
ENABLE 活动的伦理批准由马拉加地区伦理委员会授予。巴塞尔大学数据保护官员认为，德尔菲协议在数据保护和安全方面符合要求。德尔菲研究的结果将构成 ENABLE 资源库结构和相关活动的基础。
