Simpson K H, Green J H, Ellis F R
Br J Clin Pharmacol. 1986 Nov;22(5):579-86. doi: 10.1111/j.1365-2125.1986.tb02938.x.
The effects of two anticholinergic drugs on heat production (derived from oxygen consumption), sweating and core and skin temperature were compared with saline placebo in five healthy volunteers, before and after exercise. There were no significant differences between the groups in resting and peak heat production after exercise. Sweat evaporation rate increased after exercise in all cases, but there was individual variation in response to the drugs. Sweat evaporation was greater after saline placebo compared with atropine, but not after glycopyrrolate compared with saline placebo or atropine. In the saline placebo group, increased sweat evaporation following exercise was reflected by an initial fall, in skin temperature. Following anticholinergic drugs, skin temperature increased after exercise without an initial decrease. Core temperature increased following exercise, but there were no significant differences between the anticholinergic drugs and saline placebo. Although clinical doses of anticholinergic drugs, when compared with saline placebo, inhibited sweating after exercise, core temperature was not significantly increased. Therefore it is suggested that non-evaporative heat loss compensated for the reduction in sweating due to anticholinergic drugs.
在五名健康志愿者中，比较了两种抗胆碱能药物与生理盐水安慰剂在运动前后对产热（由耗氧量得出）、出汗以及核心体温和皮肤温度的影响。运动后静息产热和峰值产热在各组之间无显著差异。所有情况下运动后汗液蒸发率均增加，但对药物的反应存在个体差异。与阿托品相比，生理盐水安慰剂后的汗液蒸发量更大，但与生理盐水安慰剂或阿托品相比，格隆溴铵后的汗液蒸发量并无差异。在生理盐水安慰剂组中，运动后汗液蒸发增加表现为皮肤温度最初下降。使用抗胆碱能药物后，运动后皮肤温度升高且无最初的下降。运动后核心体温升高，但抗胆碱能药物与生理盐水安慰剂之间无显著差异。尽管与生理盐水安慰剂相比，临床剂量的抗胆碱能药物在运动后抑制了出汗，但核心体温并未显著升高。因此，提示非蒸发散热补偿了抗胆碱能药物导致的出汗减少。
