Beijing Aier-Intech Eye Hospital, Beijing, 100021, China.
Beijing Tongren Eye Center, Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, National Engineering Research Center for Ophthalmology, #1 Dong Jiao Min Xiang, Beijing, 100730, China.
BMC Ophthalmol. 2023 Oct 30;23(1):439. doi: 10.1186/s12886-023-03178-8.
To evaluate the relationship between amount of corneal refractive change (CRC) after wearing orthokeratology (Ortho-K) lenses and axial length (AL) growth.
We retrospectively enrolled 77 patients (77 eyes) aged 8-14 years who wore Ortho-K lenses more than 12 months. We divided the patients into 2 subgroups: spherical equivalent (SE) ≤ -3.0 D and SE > -3.0 D subgroup. The sagittal and tangential curvature maps and corneal topographic data within the 8-mm diameter ring at the baseline and during follow-up visits after wearing Ortho-K lens were recorded in addition to the area, height, and volume of the CRC region. The AL data were recorded at the baseline and during follow-up visits. Multivariate linear regression was conducted to analyze associations between the area, height, and volume of the CRC region, AL elongation, and SE.
The average change in the CRC region was 9.77 ± 0.60 D in height, 16.66 ± 3.61 mm in area, and 87.47 ± 8.96 D*mm in volume on the tangential diagram after wearing Ortho-K lenses for 3 months. The AL showed a change of 0.19 ± 0.14 mm after 1 year of Ortho-K lens wear (P < 0.05). At 1 year, AL elongation was negatively correlated with the area (P = 0.019) and volume (P < 0.001) of the CRC region. At 1 year, for every 1-mm increase in the area and every 1-D*mm increase in the volume of the CRC region, the average AL elongation decreased by 0.01 mm and 0.002 mm, respectively, in the multivariate analysis. In patients with SE ≤ -3.0 D, AL elongation was negatively correlated with the CRC-region volume (β = -0.002, P = 0.018), and in patients with SE > -3.0 D, AL elongation was negatively correlated with the CRC-region area (β = -0.017, P = 0.016).
The AL elongation-control efficacy of Ortho-K lenses may be related to the area and volume of the CRC region.
评估角膜屈光变化量（CRC）与眼轴（AL）增长之间的关系。
我们回顾性纳入了 77 名（77 只眼）年龄为 8-14 岁的患者，他们佩戴角膜塑形镜（Ortho-K）超过 12 个月。我们将患者分为两组：等效球镜（SE）≤-3.0 D 组和 SE>-3.0 D 组。记录基线和佩戴角膜塑形镜后随访期间的矢状和切向曲率图以及 8mm 直径环内的角膜地形图数据，同时记录 CRC 区域的面积、高度和体积。在基线和随访期间记录 AL 数据。采用多元线性回归分析 CRC 区域面积、高度和体积、AL 伸长率和 SE 之间的关系。
佩戴角膜塑形镜 3 个月后，在切线图上，CRC 区域的平均高度变化为 9.77±0.60 D，面积变化为 16.66±3.61 mm，体积变化为 87.47±8.96 D*mm。佩戴角膜塑形镜 1 年后，AL 增长 0.19±0.14 mm（P<0.05）。1 年后，AL 伸长率与 CRC 区域的面积（P=0.019）和体积（P<0.001）呈负相关。在多元分析中，1 年时，CRC 区域面积每增加 1mm，体积每增加 1-D*mm，平均 AL 伸长率分别减少 0.01mm 和 0.002mm。在 SE≤-3.0 D 的患者中，AL 伸长率与 CRC 区域体积呈负相关（β=-0.002，P=0.018），在 SE>-3.0 D 的患者中，AL 伸长率与 CRC 区域面积呈负相关（β=-0.017，P=0.016）。
角膜塑形镜的 AL 伸长率控制效果可能与 CRC 区域的面积和体积有关。
