Ellermann Frowin, Pravdivtsev Andrey, Hövener Jan-Bernd
Section for Biomedical Imaging, Molecular Imaging North Competence Center (MOIN CC), Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein (UKSH), Kiel University, Kiel 24118, Germany.
Magn Reson (Gott). 2021 Feb 18;2(1):49-62. doi: 10.5194/mr-2-49-2021. eCollection 2021.
The signal of magnetic resonance imaging (MRI) can be enhanced by several orders of magnitude using hyperpolarization. In comparison to a broadly used dynamic nuclear polarization (DNP) technique that is already used in clinical trials, the parahydrogen (H-based hyperpolarization approaches are less cost-intensive, are scalable, and offer high throughput. However, a H generator is necessary. Available commercial H generators are relatively expensive (EUR 10 000-150 000). To facilitate the spread of H-based hyperpolarization studies, here we provide the blueprints and 3D models as open-source for a low-cost (EUR ) 50-bar liquid-nitrogen-cooled H generator.
使用超极化技术，磁共振成像（MRI）信号可增强几个数量级。与已用于临床试验的广泛使用的动态核极化（DNP）技术相比，仲氢（基于H₂）超极化方法成本较低、可扩展且通量高。然而，需要一个H₂发生器。现有的商用H₂发生器相对昂贵（10,000 - 150,000欧元）。为促进基于H₂的超极化研究的推广，在此我们提供一个低成本（50巴液氮冷却的H₂发生器的蓝图和3D模型作为开源资源。
