Department of Life Science, Chung-Ang University, 06974 Seoul, Republic of Korea.
Department of Microbiology, College of Medicine, Ewha Womans University, 07804 Seoul, Republic of Korea.
Front Biosci (Landmark Ed). 2023 Oct 17;28(10):237. doi: 10.31083/j.fbl2810237.
Several antiviral drugs are clinically approved to treat influenza that is a highly prevalent acute respiratory disease. However, emerging drug-resistant virus strains undermine treatment efficacy, highlighting the exigency for novel antiviral drugs to counter these drug-resistant strains. Plants and their derivates have been historically utilized as medicinal remedies, and extensive studies have evidenced the antiviral potential of phytochemicals. Notably, apigenin is a predominant flavonoid with minimal toxicity and substantial therapeutic effects in various disease models. Despite its many anti-inflammatory, anti-oxidant, anti-cancer, anti-bacterial, and other beneficial bioactivities, existing reviews have yet to focus on apigenin's antiviral effects. Therefore, this review elucidates apigenin's therapeutic and antiviral properties and , discussing its mode of action and future prospects. Apigenin's remarkable inhibition by modulating multiple mechanisms against viruses has promising potential for novel plant-derived antiviral drugs and further clinical study developments.
几种抗病毒药物已被临床批准用于治疗流感，这是一种高度流行的急性呼吸道疾病。然而，新兴的耐药病毒株削弱了治疗效果，这凸显了开发新型抗病毒药物以对抗这些耐药菌株的紧迫性。植物及其衍生物历来被用作药物治疗方法，广泛的研究证明了植物化学物质的抗病毒潜力。值得注意的是，芹菜素是一种主要的类黄酮，在各种疾病模型中具有最小的毒性和显著的治疗效果。尽管它具有许多抗炎、抗氧化、抗癌、抗菌和其他有益的生物活性，但现有的综述尚未关注芹菜素的抗病毒作用。因此，本综述阐述了芹菜素的治疗和抗病毒特性，并讨论了其作用机制和未来前景。芹菜素通过调节多种机制对病毒的显著抑制作用，为新型植物来源的抗病毒药物和进一步的临床研究发展提供了有希望的潜力。
