Chen Wei, Li Chuling, Chen Yijin, Bin Jianping, Chen Yanmei
Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Guangzhou, China.
Front Cardiovasc Med. 2023 Oct 18;10:1237208. doi: 10.3389/fcvm.2023.1237208. eCollection 2023.
Cardiac repair after myocardial infarction (MI) is orchestrated by multiple intrinsic mechanisms in the heart. Identifying cardiac cell heterogeneity and its effect on processes that mediate the ischemic myocardium repair may be key to developing novel therapeutics for preventing heart failure. With the rapid advancement of single-cell transcriptomics, recent studies have uncovered novel cardiac cell populations, dynamics of cell type composition, and molecular signatures of MI-associated cells at the single-cell level. In this review, we summarized the main findings during cardiac repair by applying single-cell transcriptomics, including endogenous myocardial regeneration, myocardial fibrosis, angiogenesis, and the immune microenvironment. Finally, we also discussed the integrative analysis of spatial multi-omics transcriptomics and single-cell transcriptomics. This review provided a basis for future studies to further advance the mechanism and development of therapeutic approaches for cardiac repair.
心肌梗死（MI）后的心脏修复由心脏中的多种内在机制协调进行。识别心脏细胞异质性及其对介导缺血心肌修复过程的影响可能是开发预防心力衰竭新疗法的关键。随着单细胞转录组学的迅速发展，最近的研究在单细胞水平上揭示了新的心脏细胞群体、细胞类型组成的动态变化以及MI相关细胞的分子特征。在这篇综述中，我们通过应用单细胞转录组学总结了心脏修复过程中的主要发现，包括内源性心肌再生、心肌纤维化、血管生成和免疫微环境。最后，我们还讨论了空间多组学转录组学和单细胞转录组学的综合分析。这篇综述为未来进一步推进心脏修复机制和治疗方法发展的研究提供了基础。
