El Hasbani Georges, Kibbi Abdul-Ghani, Jawad Ali, Uthman Imad
Medicine, St. Vincent's Medical Center, Bridgeport, USA.
Dermatology, American University of Beirut Medical Center, Beirut, LBN.
Cureus. 2023 Oct 3;15(10):e46412. doi: 10.7759/cureus.46412. eCollection 2023 Oct.
Sjögren's syndrome (SS) has been widely known for its dry mouth and dry eyes presentation. Extraglandular disease manifestations may be protean and pose a challenge for clinicians, especially when the typical known manifestations are absent. Skin involvement of SS is variable, and cutaneous signs and symptoms may be the initial presentation of this syndrome. Vacuolar interface dermatitis has been linked to dermatomyositis and systemic lupus erythematosus, but rarely to SS. Herein, we present the case of an 87-year-old man who presented for widespread itchy erythematous scaly plaques that were refractory to topical corticosteroids as well as discontinuation of possible offending medications. A biopsy demonstrated vacuolar interface dermatitis in the setting of strongly positive anti-SSA. Hydroxychloroquine treatment was effective in resolving the plaques.
干燥综合征（SS）因其口干和眼干症状而广为人知。腺外疾病表现可能多种多样，给临床医生带来挑战，尤其是在缺乏典型已知表现时。SS的皮肤受累情况各异，皮肤体征和症状可能是该综合征的首发表现。空泡性界面皮炎与皮肌炎和系统性红斑狼疮有关，但与SS的关联很少。在此，我们报告一例87岁男性患者，其出现广泛的瘙痒性红斑鳞屑斑块，外用糖皮质激素及停用可能的致病药物均无效。活检显示在抗SSA强阳性的情况下有空泡性界面皮炎。羟氯喹治疗有效消除了斑块。
