Chang M A, Fournier G, Koh H K, Sober A J, Nakagawa H, Fitzpatrick T B, Albert D M
Graefes Arch Clin Exp Ophthalmol. 1986;224(6):529-35. doi: 10.1007/BF02154741.
Several varieties of ocular pathology are associated with acquired cutaneous hypomelanosis (leukoderma; vitiligo). Our current study was undertaken to investigate the relationship between ophthalmologic disorders and a specific depigmentary phenomenon, the vitiligolike leukoderma of cutaneous melanoma. Over the past 14 years, eight patients with cutaneous melanoma and widespread areas of hypopigmentation were identified at the Pigmented Lesion Clinic of the Massachusetts General Hospital. The seven patients who underwent ophthalmologic examination had pigment-related ocular abnormalities. Among these were inflammations of the uveal tract in three patients, heterochromia in two, halo nevi of the choroid in one, and hypopigmentation and/or atrophy of the retinal pigment epithelium or choroid in four. Our findings demonstrate that ocular disease may be a component in a syndrome consisting also of cutaneous melanoma and vitiligolike leukoderma and suggest the need for complete ophthalmologic examinations in patients with melanoma and leukoderma.
几种眼部病理类型与后天性皮肤色素减退（白斑病；白癜风）相关。我们目前的研究旨在调查眼科疾病与一种特定的色素脱失现象——皮肤黑色素瘤的白癜风样白斑病之间的关系。在过去14年中，马萨诸塞州总医院色素沉着病变诊所确诊了8例患有皮肤黑色素瘤且有大面积色素减退区域的患者。接受眼科检查的7例患者存在与色素相关的眼部异常。其中3例患者患有葡萄膜炎症，2例患者有虹膜异色，1例患者有脉络膜晕痣，4例患者有视网膜色素上皮或脉络膜色素减退和/或萎缩。我们的研究结果表明，眼部疾病可能是一种综合征的组成部分，该综合征还包括皮肤黑色素瘤和白癜风样白斑病，并提示对患有黑色素瘤和白斑病的患者需要进行全面的眼科检查。
