School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Fitoterapia. 2024 Jan;172:105736. doi: 10.1016/j.fitote.2023.105736. Epub 2023 Nov 7.
Four rare compounds (1-4), including one 1,4-epoxy-benzoxepane derivative and one ringed prenylated naphthoquinoid skeleton, as well as one isopimarane-type diterpenoid and one megastigmane-type glycoside, along with three known megastigmane-type glycosides (5-7) were isolated from the ethanol extracts of C. chinense. Their structures were determined on the basis of 1D, 2D NMR, HR-ESI-MS and DP4+ analysis. Meanwhile, the in vitro evaluation indicated that compound 2 and 6 exhibited excellent procoagulant activities, which can significantly shorten prothrombin time (PT) and activated partial thromboplastin time (APTT), respectively.
从中国扁柏（C. chinense）的乙醇提取物中分离得到了四种稀有化合物（1-4），包括一种 1,4-环氧苯并二氧戊烷衍生物和一种环状 prenylated 萘醌骨架，以及一种异松脂烷型二萜和一种 megastigmane 型糖苷，以及三种已知的 megastigmane 型糖苷（5-7）。基于 1D、2D NMR、HR-ESI-MS 和 DP4+分析确定了它们的结构。同时，体外评价表明，化合物 2 和 6 表现出优异的促凝血活性，分别能显著缩短凝血酶原时间（PT）和活化部分凝血活酶时间（APTT）。
