从患有泌尿系统疾病患者的尿液样本中分离出的两株菌株的全基因组序列草图数据集。
The dataset on the draft whole-genome sequences of two strains isolated from urine samples of patients with urinary tract diseases.
作者信息
Valeeva L R, Pudova D S, Khabipova N N, Shigapova L H, Shagimardanova E I, Rogov A M, Tagirova T R, Gimadeev Z G, Sharipova M R
机构信息
Laboratory of Agrobioengineering, Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, Parizhskoy Kommuny Str., 9, Kazan 420021, Russia.
'Regulatory genomics' Research Center, Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, Volkova Str. 18, Kazan 420012, Russia.
出版信息
Data Brief. 2023 Oct 20;51:109704. doi: 10.1016/j.dib.2023.109704. eCollection 2023 Dec.
is a widespread multidrug-resistant opportunistic human pathogen with an extremely high mortality rate that leads to urinary tract infection morbidities in particular. Variability and dynamics in genome features and ecological flexibility help these bacteria adapt to many environments and hosts and underlie their broad antibiotic resistance. Overall, studies aimed at obtaining a deeper understanding of the genome organization of UTI-associated strains are of high importance for sustainable health care worldwide. Herein, we report the draft assembly of entire genomes of two strains, PA18 and PA23, isolated from voided urine of patients with urinary tract diseases (hydronephrosis and urolithiasis, respectively) and determine the most important genetic features for pathogenesis and virulence. Whole-genome sequencing and annotation of genomes revealed high similarity between the two UTI strains along with differences in comparison with other uropathogenic and reference strains. The 6 981 635 bp and 6 948 153 bp draft genome sequences with GC contents of 65.9% and 65.8%, respectively, provide new insights into the virulence genetic factors and genes associated with antimicrobial resistance. The whole genome data of PA18 and PA23 have been deposited in the NCBI GenBank database (accession numbers JAQRBF000000000.1 and JAQRBG000000000.1, respectively).
是一种广泛存在的多重耐药性机会性人类病原体，死亡率极高，尤其会导致尿路感染发病。基因组特征的变异性和动态性以及生态灵活性有助于这些细菌适应多种环境和宿主，并构成其广泛抗生素耐药性的基础。总体而言，旨在更深入了解与尿路感染相关菌株基因组组织的研究对于全球可持续医疗保健至关重要。在此，我们报告了从患有泌尿系统疾病（分别为肾积水和尿路结石）患者的晨尿中分离出的两株菌株PA18和PA23的全基因组草图组装情况，并确定了其发病机制和毒力的最重要遗传特征。全基因组测序和基因组注释显示，这两株尿路感染菌株之间具有高度相似性，与其他尿路致病性菌株和参考菌株相比也存在差异。分别具有6981635 bp和6948153 bp的草图基因组序列，GC含量分别为65.9%和65.8%，为毒力遗传因子和与抗菌药物耐药性相关的基因提供了新的见解。PA18和PA23的全基因组数据已存入NCBI GenBank数据库（登录号分别为JAQRBF000000000.1和JAQRBG000000000.1）。
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