Rainbow T C
Neurochem Res. 1979 Jun;4(3):297-312. doi: 10.1007/BF00963800.
A brief review is given of experiments which are concerned with the hypothesis that brain RNA and protein synthesis are directly involved in the establishment of long-term memory. It is concluded that these experiments neither support or refute this hypothesis. A convincing demonstration is lacking of interanimal memory transfer by injection of macromolecular extracts. The majority of experiments which attempt to correlate increased macromolecular synthesis with learning use radioactive precursor methods and these studies do not exclude possible changes in precursor specific activity as the cause of the increased labeling. Although some studies find directly observable changes in brain macromolecules in response to training, their relationship to memory formation is unclear. It is possible that these changes represent only an enhanced production of constitutive macromolecules in response to an increase in cerebral metabolism during training, rather than molecular changes that are directly involved with modifying synaptic connectivity. Inhibitors of cerebral protein synthesis block memory formation, but these drugs are not pharmacologically specific and this complicates the interpretation of these studies.
本文简要回顾了一些实验，这些实验涉及大脑RNA和蛋白质合成直接参与长期记忆形成的假说。结论是，这些实验既不支持也不反驳这一假说。缺乏通过注射大分子提取物进行动物间记忆转移的令人信服的证明。大多数试图将大分子合成增加与学习相关联的实验使用放射性前体方法，而这些研究并未排除前体比活性的可能变化是标记增加的原因。尽管一些研究发现大脑大分子在训练后有直接可观察到的变化，但其与记忆形成的关系尚不清楚。这些变化可能仅代表在训练期间大脑代谢增加时组成型大分子产量的增加，而不是直接参与改变突触连接性的分子变化。大脑蛋白质合成抑制剂会阻断记忆形成，但这些药物在药理学上不具有特异性，这使得这些研究的解释变得复杂。
