Sandalova Elena, Maier Andrea B
Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Centre for Healthy Longevity, @AgeSingapore, National University Health System, Singapore, Singapore.
Biogerontology. 2024 Jun;25(3):423-431. doi: 10.1007/s10522-023-10077-4. Epub 2023 Nov 16.
Chronological age is the most important risk factor for the incidence of age-related diseases. The pace of ageing determines the magnitude of that risk and can be expressed as biological age. Targeting fundamental pathways of human aging with geroprotectors has the potential to lower the biological age and therewith prolong the healthspan, the period of life one spends in good health. Target populations for geroprotective interventions should be chosen based on the ageing mechanisms being addressed and the expected effect of the geroprotector on the primary outcome. Biomarkers of ageing, such as DNA methylation age, can be used to select populations for geroprotective interventions and as a surrogate outcome. Here, the use of DNA methylation clocks for selecting target populations for geroprotective intervention is explored.
实足年龄是与年龄相关疾病发病率的最重要风险因素。衰老速度决定了该风险的大小，并且可以表示为生物学年龄。使用老年保护剂针对人类衰老的基本途径，有可能降低生物学年龄，从而延长健康期，即人们保持健康的生命阶段。应根据所针对的衰老机制以及老年保护剂对主要结局的预期效果来选择老年保护干预的目标人群。衰老生物标志物，如DNA甲基化年龄，可用于选择老年保护干预的人群，并作为替代结局。在此，探讨了使用DNA甲基化时钟来选择老年保护干预的目标人群。
