Azghar Ali, Azizi Manal, Lahmer Mohammed, Benaissa Elmostapha, Ben Lahlou Yassine, Benajiba Noufissa, Elouennass Mostafa, Maleb Adil
Laboratory of Microbiology, Mohammed VI University Hospital/Faculty of Medicine and Pharmacy (University Mohammed the First), Oujda, Morocco.
Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health (LBBES)/Research Team "Cell Biology and Pharmacology Applied to Health Sciences/Faculty of Medicine and Pharmacy (University Mohammed the First), Oujda, Morocco.
Access Microbiol. 2023 Oct 13;5(10):000439. doi: 10.1099/acmi.0.000439. eCollection 2023.
() is a Gram-positive coccus of the family . It can be found in a variety of vegetables and dairy products. is an opportunistic pathogen with intrinsic resistance to vancomycin and teicoplanin. In this case report, we discuss a rare case of -associated bacteraemia in a patient with osteopetrosis. A 4-year-old girl was admitted to the paediatric emergency department with acute fever without other signs. Blood culture revealed an infection with . Using the streptococcus antibiogram, the isolate was resistant to vancomycin, teicoplanin, rifampicin and sulfamethoxazole-trimethoprim but sensitive to β-lactams, gentamicin, streptomycin, azithromycin, clarithromycin, lincomycin, clindamycin and erythromycin. The patient was treated with intravenous ceftriaxone and gentamicin, and subsequently with oral amoxicillin. After a favourable course, she was discharged from the hospital on the 10th day. The modes of transmission and physiopathology of remain unknown. Factors associated with this infection include compromised immunity, previous antibiotic therapy especially with vancomycin, and application of a central venous catheter. In our patient, the risk factors for infection were pancytopenia and multiple transfusions used to treat bone marrow failure. The source of the bacteraemia could have been the cutaneous route, but it could also have been digestive due to the reservoir of the bacteria. is known as an opportunistic bacterium. Further studies on its pathogenesis and other risk factors are needed to understand the true prevalence of this potentially fatal bacterium in compromised individuals, such as the case of our patient.
（）是 科的革兰氏阳性球菌。它可在多种蔬菜和乳制品中发现。（）是一种对万古霉素和替考拉宁具有内在耐药性的机会致病菌。在本病例报告中，我们讨论了一名患有骨质石化症的患者发生罕见的与（）相关的菌血症病例。一名4岁女孩因急性发热被收入儿科急诊科，无其他体征。血培养显示感染了（）。根据链球菌抗菌谱，分离株对万古霉素、替考拉宁、利福平及磺胺甲恶唑 - 甲氧苄啶耐药，但对β - 内酰胺类、庆大霉素、链霉素、阿奇霉素、克拉霉素、林可霉素、克林霉素和红霉素敏感。患者接受了静脉注射头孢曲松和庆大霉素治疗，随后口服阿莫西林。经过良好的病程，她于第10天出院。（）的传播方式和病理生理学仍不清楚。与这种感染相关的因素包括免疫功能受损、先前的抗生素治疗尤其是使用万古霉素，以及中心静脉导管的应用。在我们的患者中，感染的危险因素是全血细胞减少和用于治疗骨髓衰竭的多次输血。菌血症的来源可能是皮肤途径，但也可能由于细菌的储存库而来自消化道。（）被认为是一种机会性细菌。需要对其发病机制和其他危险因素进行进一步研究，以了解这种潜在致命细菌在免疫功能受损个体中的真实流行情况，如我们患者的病例。
