胃癌中与二硫化物诱导细胞程序性坏死相关基因及预后的综合分析
Comprehensive analysis of disulfidptosis related genes and prognosis of gastric cancer.
作者信息
Li Qian, Yin Long-Kuan
机构信息
Department of Oncology, Fushun Hospital of Traditional Chinese Medicine, Zigong 643200, Sichuan Province, China.
Department of Gastrointestinal Surgery, Fushun People's Hospital, Zigong 643200, Sichuan Province, China.
出版信息
World J Clin Oncol. 2023 Oct 24;14(10):373-399. doi: 10.5306/wjco.v14.i10.373.
BACKGROUND
Gastric cancer (GC) is a common malignant tumor of the digestive system. Disulfidptosis is a new programmed cell death mechanism, although its specific mechanism in GC is incompletely understood.
AIM
In this study, we used bioinformatics analysis to explore a disulfidptosis-based predictive model related to GC prognosis and to identify potential therapeutic targets and sensitive drugs for GC.
METHODS
We extracted GC-related data from The Cancer Genome Atlas and Gene Expression Omnibus databases. R software (version 4.2.1) was used for correlation analysis.
RESULTS
Through the above analysis, we found that the disulfidptosis related gene may be related to the prognosis of GC. Six genes, namely, , , , , , and , were found to constitute a predictive model for GC prognosis. is a potential therapeutic target for treating GC. Bosutinib and other drugs are sensitive for the treatment of GC.
CONCLUSION
The results of this study indicate that disulfidptosis is related to the prognosis and treatment of GC, while represents a potential therapeutic target for GC.
背景
胃癌（GC）是消化系统常见的恶性肿瘤。二硫化物诱导的细胞死亡是一种新的程序性细胞死亡机制，尽管其在胃癌中的具体机制尚不完全清楚。
目的
在本研究中，我们使用生物信息学分析来探索基于二硫化物诱导的细胞死亡的胃癌预后预测模型，并确定胃癌的潜在治疗靶点和敏感药物。
方法
我们从癌症基因组图谱和基因表达综合数据库中提取了与胃癌相关的数据。使用R软件（版本4.2.1）进行相关性分析。
结果
通过上述分析，我们发现二硫化物诱导的细胞死亡相关基因可能与胃癌的预后有关。发现六个基因，即 、 、 、 、 和 ，构成了胃癌预后的预测模型。 是治疗胃癌的潜在治疗靶点。博舒替尼等药物对胃癌治疗敏感。
结论
本研究结果表明，二硫化物诱导的细胞死亡与胃癌的预后和治疗有关，而 代表了胃癌的潜在治疗靶点。
Zotero 插件