Department of General Surgery, The Second Xiangya Hospital of Central South University, Changsha, 410011, China.
Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, 410011, China.
Sci Rep. 2023 Jul 31;13(1):12403. doi: 10.1038/s41598-023-39563-y.
Colon adenocarcinoma (COAD) is a type of cancer that arises from the glandular epithelial cells that produce mucus in the colon. COAD is influenced by various factors, including genetics, environment and lifestyle. The outcome of COAD is determined by the tumor stage, location, molecular characteristics and treatment. Disulfidptosis is a new mode of cell death that may affect cancer development. We discovered genes associated with disulfidptosis in colon adenocarcinoma and proposed them as novel biomarkers and therapeutic targets for COAD. We analyzed the mRNA expression data and clinical information of COAD patients from The Cancer Genome Atlas (TCGA) database and Xena databases, extracted disulfidptosis-related genes from the latest reports on disulfidptosis. We used machine learning to select key features and build a signature and validated the risk model using data from the Gene Expression Omnibus (GEO) database and Human Protein Atlas (HPA). We also explored the potential biological functions and therapeutic implications of the disulfidptosis-related genes using CIBERSORTx and GDSC2 databases. We identified four disulfidptosis-related genes: TRIP6, OXSM, MYH3 and MYH4. These genes predicted COAD patient survival and modulated the tumor microenvironment, drug sensitivity and immune microenvironment. Our study reveals the importance of disulfidptosis-related genes for COAD prognosis and therapy. Immune infiltration and drug susceptibility results provide important clues for finding new personalized treatment options for COAD. These findings may facilitate personalized cancer treatment.
结肠腺癌（COAD）是一种起源于结肠中产生粘液的腺上皮细胞的癌症。COAD 受多种因素影响，包括遗传、环境和生活方式。COAD 的结局取决于肿瘤分期、位置、分子特征和治疗。二硫键凋亡是一种新的细胞死亡方式，可能影响癌症的发展。我们在结肠腺癌中发现了与二硫键凋亡相关的基因，并将其提出作为 COAD 的新型生物标志物和治疗靶点。我们分析了来自癌症基因组图谱（TCGA）数据库和 Xena 数据库的 COAD 患者的 mRNA 表达数据和临床信息，从最新的二硫键凋亡报告中提取了二硫键凋亡相关基因。我们使用机器学习选择关键特征并构建签名，并使用来自基因表达综合（GEO）数据库和人类蛋白质图谱（HPA）的数据验证风险模型。我们还使用 CIBERSORTx 和 GDSC2 数据库探索了二硫键凋亡相关基因的潜在生物学功能和治疗意义。我们确定了四个二硫键凋亡相关基因：TRIP6、OXSM、MYH3 和 MYH4。这些基因预测了 COAD 患者的生存情况，并调节了肿瘤微环境、药物敏感性和免疫微环境。我们的研究揭示了二硫键凋亡相关基因对 COAD 预后和治疗的重要性。免疫浸润和药物敏感性结果为寻找 COAD 的新个性化治疗方案提供了重要线索。这些发现可能有助于癌症的个性化治疗。
