Golovach Iryna, Rekalov Dmytro, Akimov Oleh Ye, Kostenko Heorhii, Kostenko Viktoriia, Mishchenko Artur, Solovyova Natalia, Kostenko Vitalii
Centre for Rheumatology, Osteoporosis and Immunobiological Therapy, Feofania Clinical Hospital of the State Affairs Administration, Kyiv, Ukraine.
Department of Internal Diseases No 3, Zaporizhzhia State Medical and Pharmaceutical University, Ukraine.
Reumatologia. 2023;61(5):395-407. doi: 10.5114/reum/172211. Epub 2023 Oct 31.
Post-traumatic osteoarthritis (PTOA), a disorder of the synovium, subchondral bone, and cartilage that affects the entire joint, constitutes approximately 12% of all cases of symptomatic osteoarthritis. This review summarizes the pathogenetic mechanisms that underlie the positive influence of chondroitin sulphates (CSs) on PTOA as means of preventive and therapeutic treatment. Mechanisms of PTOA development involve chondrocytes undergoing various forms of cell death (apoptosis, pyroptosis, necroptosis, ferroptosis and/or necrosis). Chondroitin sulphates are a class of glycosaminoglycans that improve the structure and function of cartilage and subchondral bone, which is associated with their ability to decrease the activation of NF-κB and p38 MAPK, and up-regulate Nrf2. Standardized small fish extract (SSFE) is an example of the drugs that can attenuate NF-κB-mediated systemic inflammation, potentially helping to reduce joint inflammation and cartilage degradation, improve joint function, and alleviate pain and disability in patients with these conditions.
创伤后骨关节炎（PTOA）是一种影响整个关节的滑膜、软骨下骨和软骨疾病，约占所有症状性骨关节炎病例的12%。本综述总结了硫酸软骨素（CSs）对PTOA产生积极影响的致病机制，作为预防和治疗手段。PTOA的发病机制涉及软骨细胞经历各种形式的细胞死亡（凋亡、焦亡、坏死性凋亡、铁死亡和/或坏死）。硫酸软骨素是一类糖胺聚糖，可改善软骨和软骨下骨的结构和功能，这与其降低NF-κB和p38 MAPK的激活以及上调Nrf2的能力有关。标准化小鱼提取物（SSFE）是一种能够减轻NF-κB介导的全身炎症的药物示例，可能有助于减轻关节炎症和软骨降解，改善关节功能，并减轻患有这些病症患者的疼痛和残疾。
