State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, China.
School of Chemical Engineering, Sichuan University, Chengdu, Sichuan, 610065, China.
Adv Mater. 2024 Jan;36(2):e2307756. doi: 10.1002/adma.202307756. Epub 2023 Nov 27.
Titanium implants are widely used ; however, implantation occasionally fails due to infections during the surgery or poor osseointegration after the surgery. To solve the problem, an intelligent functional surface on titanium implant that can sequentially eradicate bacteria biofilm at the initial period and promote osseointegration at the late period of post-surgery time is designed. Such surfaces can be excited by near infrared light (NIR), with rare earth nanoparticles to upconvert the NIR light to visible range and adsorb by Au nanoparticles, supported by titanium oxide porous film on titanium implants. Under NIR irradiation, the implant converts the energy of phonon to hot electrons and lattice vibrations, while the former flows directly to the contact substance or partially reacts with the surrounding to generate reactive oxygen species, and the latter leads to the local temperature increase. The biofilm or microbes on the implant surface can be eradicated by NIR treatment in vitro and in vivo. Additionally, the surface exhibits superior biocompatibility for cell survival, adhesion, proliferation, and osteogenic differentiation, which provides the foundation for osseointegration. In vivo implantation experiments demonstrate osseointegration is also promoted. This work thus demonstrates NIR-generated electrons can sequentially eradicate biofilms and regulate the osteogenic process, providing new solutions to fabricate efficient implant surfaces.
钛植入物被广泛应用；然而，由于手术过程中的感染或手术后骨整合不良，植入物偶尔会失效。为了解决这个问题，设计了一种钛植入物的智能功能表面，该表面可以在手术后的早期阶段顺序消除细菌生物膜，在后期促进骨整合。这种表面可以被近红外光（NIR）激发，利用稀土纳米粒子将 NIR 光上转换到可见光范围，并通过钛氧化物多孔膜上的金纳米粒子吸附。在 NIR 照射下，植入物将声子的能量转化为热电子和晶格振动，而前者直接流向接触物质或与周围环境部分反应生成活性氧物质，后者导致局部温度升高。植入物表面的生物膜或微生物可以通过体外和体内的 NIR 处理来消除。此外，该表面对细胞存活、黏附、增殖和成骨分化表现出优异的生物相容性，为骨整合提供了基础。体内植入实验表明，骨整合也得到了促进。因此，这项工作证明了 NIR 产生的电子可以顺序消除生物膜并调节成骨过程，为制造高效植入物表面提供了新的解决方案。
