揭示炎症和血小板标志物对中央视网膜动脉阻塞的预测能力。
Unveiling the predictive capacity of inflammatory and platelet markers for central retinal artery occlusion.
机构信息
Department of Ophthalmology, Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical University, 261000 Weifang, Shandong, China.
Department of Ophthalmology, Affiliated Hospital of Weifang Medical University, 261000 Weifang, Shandong, China.
出版信息
Thromb Res. 2023 Dec;232:108-112. doi: 10.1016/j.thromres.2023.11.004. Epub 2023 Nov 11.
OBJECTIVES
Cell counting in peripheral blood samples and their combinations have gained wide usage in clinical research due to their convenient and minimally invasive sampling method. This study aims to evaluate the predictive value of neutrophil-to-lymphocyte ratio (NLR), systemic Immunoinflammatory Index (SII), and systemic Inflammatory Response Index (SIRI), and platelet distribution width (PDW) for the occurrence of non-arteritic Central retinal artery occlusion (NA-CRAO).
METHODS
We included 123 patients diagnosed with NA-CRAO and 120 age-, sex- and blood pressure-matched individuals in this study. All participants underwent a comprehensive ophthalmic assessment. Peripheral blood samples were retrospectively analysed to obtain patients' blood counts and platelet-related indices, and further NLR, SII and SIRI were calculated.
RESULTS
NLR, SII, SIRI, and PDW were all found to be elevated and significantly different in NA-CRAO patients compared to controls (p < 0.05). Notably, elevated NLR and PDW were identified as independent influences on the development of NA-CRAO, with a combined predicted AUC of 0.876.
CONCLUSION
The utilization of NLR and PDW in NA-CRAO prediction may prove to be more effective compared to SII and SIRI.
目的
外周血样本的细胞计数及其组合因其便捷、微创的采样方法，在临床研究中得到了广泛应用。本研究旨在评估中性粒细胞与淋巴细胞比值（NLR）、全身免疫炎症指数（SII）和全身炎症反应指数（SIRI）以及血小板分布宽度（PDW）对非动脉炎性中央视网膜动脉阻塞（NA-CRAO）发生的预测价值。
方法
本研究纳入了 123 例诊断为 NA-CRAO 的患者和 120 例年龄、性别和血压匹配的个体。所有参与者均接受了全面的眼科评估。回顾性分析外周血样本以获取患者的血细胞计数和血小板相关指标，并进一步计算 NLR、SII 和 SIRI。
结果
与对照组相比，NA-CRAO 患者的 NLR、SII、SIRI 和 PDW 均升高且差异有统计学意义（p<0.05）。值得注意的是，升高的 NLR 和 PDW 被确定为影响 NA-CRAO 发展的独立因素，联合预测 AUC 为 0.876。
结论
与 SII 和 SIRI 相比，NLR 和 PDW 在 NA-CRAO 预测中的应用可能更为有效。
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