Yim Sung Sun, Wang Harris H
Department of Systems Biology, Columbia University, New York, NY, USA.
Department of Pathology and Cell Biology, Columbia University, New York, NY, USA.
Curr Opin Biomed Eng. 2021 Sep;19. doi: 10.1016/j.cobme.2021.100307. Epub 2021 Jun 4.
Interbacterial antagonism can significantly impact microbiome assembly and stability and can potentially be exploited to modulate microbes and microbial communities in diverse environments, ranging from natural habitats to industrial bioreactors. Here we highlight key mechanisms of interspecies antagonism that rely on direct cell-to-cell contact or diffusion of secreted biomolecules, and discuss recent advances to provide altered function and specificities for microbiome engineering. We further outline the use of ecological design principles based on antagonistic interactions for bottom-up assembly of synthetic microbial communities. Manipulating microbial communities through these negative interactions will be critical for understanding complex microbiome processes and properties and developing new applications of microbiome engineering.
细菌间的拮抗作用可显著影响微生物群落的组装和稳定性，并有可能被用于调控各种环境中的微生物及微生物群落，这些环境涵盖了从自然栖息地到工业生物反应器等多个领域。在此，我们重点介绍了依赖细胞间直接接触或分泌生物分子扩散的种间拮抗作用的关键机制，并讨论了为微生物群落工程提供功能改变和特异性的最新进展。我们还概述了基于拮抗相互作用的生态设计原则在合成微生物群落自下而上组装中的应用。通过这些负相互作用来操纵微生物群落对于理解复杂的微生物群落过程和特性以及开发微生物群落工程的新应用至关重要。
