ECE, Worcester Polytech. Inst., 100 Institute Rd. Worcester MA 01609-2280, United States of America.
Ansys, Inc., Boston Campus, 400 5th Ave Suite 500, Waltham MA 02451, United States of America.
Biomed Phys Eng Express. 2023 Nov 30;10(1). doi: 10.1088/2057-1976/ad0e14.
Transcranial magnetic stimulation (TMS) studies with small animals can provide useful knowledge of activating regions and mechanisms. Along with this, functional magnetic resonance imaging (fMRI) in mice and rats is increasingly often used to draw important conclusions about brain connectivity and functionality. For cases of both low- and high-frequency TMS studies, a high-quality computational surface-based rodent model may be useful as a tool for performing supporting modeling and optimization tasks. This work presents the development and usage of an accurate CAD model of a mouse that has been optimized for use in computational electromagnetic modeling in any frequency range. It is based on the labeled atlas data of the Digimouse archive. The model includes a relatively accurate four-compartment brain representation (the 'whole brain' according to the original terminology, external cerebrum, cerebellum, and striatum [9]) and contains 21 distinct compartments in total. Four examples of low- and high frequency modeling have been considered to demonstrate the utility and applicability of the model.
经颅磁刺激(TMS)研究在小动物身上进行,可以提供激活区域和机制的有用知识。与此同时,功能磁共振成像(fMRI)在小鼠和大鼠中的应用也越来越广泛,这为研究大脑连接和功能提供了重要结论。对于低频和高频 TMS 研究,高质量的基于计算的啮齿动物表面模型可能是一种有用的工具,可以用于执行支持建模和优化任务。本工作提出了一种优化用于任何频率范围内计算电磁建模的小鼠精确 CAD 模型的开发和使用。它基于 Digimouse 档案的标记图谱数据。该模型包括一个相对准确的四腔脑表示(根据原始术语,外部大脑、小脑和纹状体[9]的“整个大脑”),总共包含 21 个不同的腔室。考虑了四个低频和高频建模的例子,以展示模型的实用性和适用性。