Department of Environmental Science and Disaster Management, Noakhali Science and Technology University, Noakhali, 3814, Bangladesh.
Department of Animal Breeding and Genetics, Bangladesh Agricultural University, Mymensingh, 2202, Bangladesh.
Environ Pollut. 2024 Jan 15;341:122972. doi: 10.1016/j.envpol.2023.122972. Epub 2023 Nov 18.
Infectious diseases are a part of everyday life, and acute respiratory diseases are the most common. Many agents carrying out respiratory infections are transmitted as bioaerosols through the air, usually, particulate matter containing living organisms. The purpose of the study is to conduct a systematic review and meta-analysis to assess the likelihood that people exposed to bioaerosols may experience severe respiratory diseases. Nine digital databases and bibliographies were assessed for papers conducted between January 1960 and April 2021. A total of 35 health and exposure studies were included from 825 studies for the systematic review, while only 17 contented the meta-inclusion analysis's criteria. This systematic review found higher bacterial bioaerosol concentrations in poultry farms, waste dumpsites, composting plants, and paper industries. The meta-analysis's Standard Mean Difference (SMD) measurement indicates a substantially positive association between bioaerosol exposure and respiratory disease outcomes in targeted populations. The value is 0.955 [95% CI, range 0.673-1.238; p < 0.001]. As per the Risk of Bias (ROB) findings, most of findings (30 out of 35 [85.71%]) were judged to have low ROB. From the random effect probit model, the total relative risk is 1.477 (95% CI, range 0.987-2.211), indicating a higher risk of respiratory diseases from bioaerosol exposure than the control groups. The total risk difference is 0.121 (95% CI, -0.0229 to 0.264), which means intervention groups may have a higher risk of respiratory diseases from continuous bioaerosol exposure than the control groups. The dose-response relationship revealed a strong positive linear coefficient correlation between bacterial & fungal bioaerosol exposure to respiratory health. Based on self-reported outcomes in those studies, The systematic review and meta-analysis stated that bioaerosol exposure had an effect on pulmonary health.
传染病是日常生活的一部分，急性呼吸道疾病最为常见。许多引起呼吸道感染的病原体作为生物气溶胶通过空气传播，通常是含有活生物体的颗粒物。本研究旨在进行系统评价和荟萃分析，以评估暴露于生物气溶胶的人是否可能患有严重呼吸道疾病。评估了 1960 年 1 月至 2021 年 4 月期间发表的 9 个数字数据库和文献目录中的论文。从 825 项研究中进行了总共 35 项健康和暴露研究，用于系统评价，而只有 17 项符合荟萃分析的纳入标准。本系统评价发现，家禽养殖场、垃圾场、堆肥厂和造纸业的细菌生物气溶胶浓度较高。荟萃分析的标准化均数差（SMD）测量表明，在目标人群中，生物气溶胶暴露与呼吸道疾病结果之间存在显著正相关。该值为 0.955 [95%置信区间，范围 0.673-1.238；p < 0.001]。根据风险偏倚（ROB）结果，大多数发现（35 项中的 30 项[85.71%]）被判断为低 ROB。从随机效应概率模型得出，总相对风险为 1.477（95%置信区间，范围 0.987-2.211），这表明生物气溶胶暴露比对照组更易导致呼吸道疾病。总风险差异为 0.121（95%置信区间，-0.0229 至 0.264），这意味着干预组可能比对照组更容易因持续的生物气溶胶暴露而患上呼吸道疾病。剂量-反应关系显示，细菌和真菌生物气溶胶暴露与呼吸道健康之间存在强烈的正线性系数相关性。基于这些研究中的自我报告结果，系统评价和荟萃分析表明，生物气溶胶暴露对肺部健康有影响。
