CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; Department of Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China; University of Chinese Academy of Sciences, Beijing 100049, China.
CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Carbohydr Polym. 2024 Jan 15;324:121555. doi: 10.1016/j.carbpol.2023.121555. Epub 2023 Nov 3.
The large-scale collections, screening and discovery of biologically active and pharmacologically significant marine-derived natural products have garnered tremendous attraction. Edible brown algae are rich in fucoidan. Importantly, fucoidan has been reported to inhibit carcinogenesis and metastasis mainly through the regulation of deregulated cell signaling pathways. This review summarizes the structural features of fucoidan, including monosaccharide type, sulfate content, and main chain structure. We have set spotlight on fucoidan-mediated tumor suppressive effects in cell cultures studies and tumor-bearing rodent models. Fucoidan exerts anti-tumor effects primarily through the inhibition of tumor cell viability, proliferation and metastatic dissemination of cancer cells from primary tumor sites to distant secondary sites. Fucoidan not only promotes immunological responses in tumor microenvironment but also induces apoptotic death in cancer cells. In addition, fucoidan can be used as a dietary supplement for preventive purposes, in combination with other drugs as complementary and alternative medicine or with nanoparticle modifications will be the future of fucoidan use. Cutting-edge research related to fucoidan has catalyzed the transition of fucoidan from preclinical studies to different phases of clinical trials. Rationally designed clinical trials for the critical evaluation of fucoidan against different cancers will be valuable to reap full benefits.
大规模收集、筛选和发现具有生物活性和药理意义的海洋来源天然产物引起了极大的关注。可食用的褐藻富含褐藻糖胶。重要的是，褐藻糖胶已被报道主要通过调节失调的细胞信号通路来抑制致癌作用和转移。本综述总结了褐藻糖胶的结构特征，包括单糖类型、硫酸酯含量和主链结构。我们重点介绍了褐藻糖胶在细胞培养研究和荷瘤啮齿动物模型中介导的肿瘤抑制作用。褐藻糖胶通过抑制肿瘤细胞活力、增殖和癌细胞从原发性肿瘤部位向远处继发性肿瘤部位的转移来发挥抗肿瘤作用。褐藻糖胶不仅促进肿瘤微环境中的免疫反应，还诱导癌细胞凋亡。此外，褐藻糖胶可用作预防目的的膳食补充剂，与其他药物联合使用作为补充和替代医学，或与纳米颗粒修饰结合将是褐藻糖胶使用的未来。与褐藻糖胶相关的前沿研究推动了褐藻糖胶从临床前研究向不同阶段临床试验的转变。针对不同癌症的褐藻糖胶进行合理设计的临床试验，对于充分利用其益处将是有价值的。
