利用第二近红外光谱中的光伏技术进行无线深部脑神经调节。
Wireless deep-brain neuromodulation using photovoltaics in the second near-infrared spectrum.
作者信息
Cui Han, Zhao Su, Hong Guosong
机构信息
Department of Materials Science and Engineering, Stanford University, Stanford, CA, 94305, USA.
Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, 94305, USA.
出版信息
Device. 2023 Oct 20;1(4). doi: 10.1016/j.device.2023.100113.
Conventional electrical neuromodulation techniques are constrained by the need for invasive implants in neural tissues, whereas methods using optogenetic are subjected to genetic alterations and hampered by the poor tissue penetration of visible light. Photovoltaic neuromodulation using light from the second near-infrared (NIR-II) spectrum, which minimizes scattering and enhances tissue penetration, shows promise as an alternative to existing neuromodulation technologies. NIR-II light has been used in deep-tissue imaging and in deep-brain photothermal neuromodulation via nanotransducers. This Perspective will provide an overview for the underpinning mechanisms of photovoltaic neuromodulation and identify avenues for future research in materials science and bioengineering that can further advance NIR-II photovoltaic neuromodulation methods.
传统的电神经调节技术受到在神经组织中进行侵入性植入的需求的限制，而使用光遗传学的方法则会受到基因改变的影响，并且由于可见光对组织的穿透性较差而受到阻碍。利用来自第二近红外（NIR-II）光谱的光进行的光伏神经调节，可将散射降至最低并增强组织穿透性，有望成为现有神经调节技术的替代方案。NIR-II光已用于深部组织成像以及通过纳米换能器进行的深部脑光热神经调节。本观点将概述光伏神经调节的基础机制，并确定材料科学和生物工程领域未来的研究方向，这些研究可以进一步推进NIR-II光伏神经调节方法。
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