College of Animal Sciences, Zhejiang University, Hangzhou, China; Key Laboratory of Molecular Animal Nutrition (Zhejiang University), Ministry of Education, China; Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, Hangzhou, China.
College of Animal Sciences, Zhejiang University, Hangzhou, China; Key Laboratory of Molecular Animal Nutrition (Zhejiang University), Ministry of Education, China; Key Laboratory of Animal Feed and Nutrition of Zhejiang Province, Hangzhou, China.
Sci Total Environ. 2024 Feb 10;911:168648. doi: 10.1016/j.scitotenv.2023.168648. Epub 2023 Nov 20.
Zearalenone (ZEA), a global mycotoxin commonly found in a variety of grain products and animal feed, causes damage to the gastrointestinal tract, immune organs, liver and reproductive system. Many treatments, including physical, chemical and biological methods, have been reported for the degradation of ZEA. Each degradation method has different degradation efficacies and distinct mechanisms. In this article, the global pollution status, hazard and toxicity of ZEA are summarized. We also review the biological detoxification methods and nutritional regulation strategies for alleviating the toxicity of ZEA. Moreover, we discuss the molecular detoxification mechanism of ZEA to help explore more efficient detoxification methods to better reduce the global pollution and hazard of ZEA.
玉米赤霉烯酮（ZEA）是一种全球性的霉菌毒素，普遍存在于各种谷物产品和动物饲料中，会对胃肠道、免疫器官、肝脏和生殖系统造成损害。已有报道称，可采用物理、化学和生物等多种方法对 ZEA 进行降解。每种降解方法的降解效果和机制都有所不同。本文总结了 ZEA 的全球污染状况、危害和毒性，综述了生物解毒方法和营养调控策略缓解 ZEA 毒性的作用机制，并讨论了 ZEA 的分子解毒机制，以期帮助探索更有效的解毒方法，从而更好地降低 ZEA 的全球污染和危害。
