病原体感染与宿主免疫中的脂滴
Lipid droplets in pathogen infection and host immunity.
机构信息
Center for Cell Structure and Function, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan, 250014, China.
Research Center of Translational Medicine, Central Hospital Affiliated to Shandong First Medical University, Jinan, 250013, China.
出版信息
Acta Pharmacol Sin. 2024 Mar;45(3):449-464. doi: 10.1038/s41401-023-01189-1. Epub 2023 Nov 22.
As the hub of cellular lipid metabolism, lipid droplets (LDs) have been linked to a variety of biological processes. During pathogen infection, the biogenesis, composition, and functions of LDs are tightly regulated. The accumulation of LDs has been described as a hallmark of pathogen infection and is thought to be driven by pathogens for their own benefit. Recent studies have revealed that LDs and their subsequent lipid mediators contribute to effective immunological responses to pathogen infection by promoting host stress tolerance and reducing toxicity. In this comprehensive review, we delve into the intricate roles of LDs in governing the replication and assembly of a wide spectrum of pathogens within host cells. We also discuss the regulatory function of LDs in host immunity and highlight the potential for targeting LDs for the diagnosis and treatment of infectious diseases.
作为细胞脂质代谢的中心，脂滴（LDs）与多种生物过程有关。在病原体感染期间，LDs 的生物发生、组成和功能受到严格调控。LDs 的积累被描述为病原体感染的一个标志，并且被认为是由病原体为了自身利益而驱动的。最近的研究表明，LDs 及其随后的脂质介质通过促进宿主应激耐受性和降低毒性，有助于对病原体感染产生有效的免疫反应。在这篇全面的综述中，我们深入探讨了 LDs 在调节宿主细胞内广泛范围的病原体复制和组装中的复杂作用。我们还讨论了 LDs 在宿主免疫中的调节功能，并强调了针对 LDs 进行诊断和治疗传染病的潜力。
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