Wang Lijun, Cui Xinxin, Jiang Fei, Hu Yuxue, Wan Wensi, Li Guoping, Lin Yanjuan, Xiao Junjie
Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, 226011, China.
Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Life Science, Shanghai University, Shanghai, 200444, China.
Curr Genomics. 2023 Oct 27;24(2):66-71. doi: 10.2174/1389202924666230911121358.
Circular RNAs (circRNAs) are a class of endogenous functional RNA generated by back-splicing. Recently, circRNAs have been found to have certain coding potential. Proteins/peptides translated from circRNAs play essential roles in various diseases. Here, we briefly summarize the basic knowledge and technologies that are usually applied to study circRNA translation. Then, we focus on the research progress of circRNA translation in cardiovascular diseases and discuss the perspective and future direction of translatable circRNA study in cardiovascular diseases.
环状RNA（circRNAs）是一类通过反向剪接产生的内源性功能性RNA。最近，人们发现circRNAs具有一定的编码潜力。从circRNAs翻译而来的蛋白质/肽在各种疾病中发挥着重要作用。在此，我们简要总结了通常用于研究circRNA翻译的基础知识和技术。然后，我们重点关注circRNA翻译在心血管疾病中的研究进展，并讨论心血管疾病中可翻译circRNA研究的前景和未来方向。
