Faculty of Environment and Life, Beijing University of Technology, Pingleyuan 100(#), District of Chaoyang, Beijing 100124, China.
Faculty of Environment and Life, Beijing University of Technology, Pingleyuan 100(#), District of Chaoyang, Beijing 100124, China.
Biochem Pharmacol. 2024 Jan;219:115933. doi: 10.1016/j.bcp.2023.115933. Epub 2023 Nov 22.
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death and has been implicated in the occurrence and development of various diseases, including heart disease, nervous system diseases and cancer. Ferroptosis induction recently emerged as an attractive strategy for cancer therapy. Ferroptosis has become a potential target for intervention in these diseases or injuries in relevant preclinical models. This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer, highlights redox status and metabolism's role in it. Combination therapy for ferroptosis has great potential in cancer treatment, especially malignant tumors that are resistant to conventional therapies. This review will lead us to have a comprehensive understanding of the future exploration of ferroptosis and cancer therapy. A deeper understanding of the relationship between ferroptosis resistance and metabolism reprogramming may provide new strategies for tumor treatment and drug development based on ferroptosis.
铁死亡是一种铁依赖性、非凋亡性的细胞死亡形式，与多种疾病的发生和发展有关，包括心脏病、神经系统疾病和癌症。铁死亡诱导最近成为癌症治疗的一种有吸引力的策略。在相关的临床前模型中，铁死亡已成为干预这些疾病或损伤的潜在靶点。本综述总结了癌症中铁死亡抵抗机制的最新进展，强调了氧化还原状态和代谢在其中的作用。铁死亡联合治疗在癌症治疗中具有巨大的潜力，特别是对传统治疗方法耐药的恶性肿瘤。本综述将使我们全面了解未来对铁死亡和癌症治疗的探索。对铁死亡抵抗与代谢重编程关系的深入了解，可能为基于铁死亡的肿瘤治疗和药物开发提供新的策略。
