Yang Gen, Qian Boning, He Liya, Zhang Chi, Wang Jianqiang, Qian Xinlai, Wang Yongxia
Department of Pathology, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453003, Henan, China.
Department of Pathology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, 453003, Henan, China.
Cancer Cell Int. 2025 Feb 21;25(1):59. doi: 10.1186/s12935-025-03641-0.
Colorectal cancer (CRC) is a serious threat to human health with the third morbidity and the second cancer-related mortality worldwide. It is urgent to explore more effective strategy for CRC because of the acquired treatment resistance from the non-surgical conventional therapies, including radiation, chemotherapy, targeted therapy and immunotherapy. Ferroptosis is a novel form of programmed cell death characterized by iron-dependent lipid peroxidation species (ROS) accumulation and has been identified as a promising target for cancer treatment, especially for those with treatment resistance. In this review, we mainly summarize the recent studies on the influence and regulation of ferroptosis by which (including gut microbiota) modulating the metabolism of iron, amino acid and lipid. Thus this analysis may provide potential targets for inducing CRC ferroptosis and shed lights on the future application of ferroptosis in CRC.
结直肠癌（CRC）是对人类健康的严重威胁，在全球发病率排名第三，癌症相关死亡率排名第二。由于包括放疗、化疗、靶向治疗和免疫治疗在内的非手术传统疗法会产生获得性治疗耐药性，因此迫切需要探索更有效的结直肠癌治疗策略。铁死亡是一种新型程序性细胞死亡形式，其特征是铁依赖性脂质过氧化物（ROS）积累，已被确定为癌症治疗的一个有前景的靶点，尤其是对于那些具有治疗耐药性的癌症。在本综述中，我们主要总结了关于铁死亡的影响和调控的最新研究，其中（包括肠道微生物群）调节铁、氨基酸和脂质的代谢。因此，该分析可能为诱导结直肠癌铁死亡提供潜在靶点，并为铁死亡在结直肠癌中的未来应用提供启示。
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