School of Materials Science and Engineering, Yeungnam University, Gyeongsan 38541, Republic of Korea.
Department of Chemistry, M.M.D.C, Moradabad, M.J.P. Rohilkhand University, Bareilly 244001, UP, India.
Biosensors (Basel). 2023 Nov 16;13(11):986. doi: 10.3390/bios13110986.
Azithromycin (AZY) is a well-known top-prioritized antibiotic and is used by humans in strong concentrations. However, the side effects of the AZY antibiotic may cause some serious and significant damage to humans and the environment. Thus, there is a need to develop effective and sensitive sensors to monitor accurate concentrations of AZY. In the last decade, electrochemistry-based sensors have received enormous attention from the scientific community because of their high sensitivity, selectivity, cost-effectiveness, fast response, rapid detection response, simple fabrication, and working principle. It is important to mention that electrochemical sensors rely on the properties of electrode modifiers. Hence, the selection of electrode materials is of great significance when designing and developing efficient and robust electrochemical sensors. In this study, we fabricated an AZY sensor by utilizing a molybdenum disulfide/titanium aluminum carbide (MoS@TiAlC) composite as the electrode material. The MoS@TiAlC composite was synthesized via a simple sonication process. The synthesized MoS@TiAlC composite was characterized using a powder X-ray diffraction (XRD) method to examine the phase purity and formation of the MoS@TiAlC composite. Scanning electron microscopy (SEM) was used to study the surface morphological features of the prepared MoS@TiAlC composite, whereas energy dispersive X-ray spectroscopy (EDAX) was adopted to determine the elemental composition of the prepared MoS@TiAlC composite. The glassy carbon (GC) electrode was modified with the prepared MoS@TiAlC composite and applied as the AZY sensor. The sensing performance of the MoS@TiAlC composite-modified GC electrode was studied using linear sweep voltammetry. The sensor demonstrated excellent performance when determining AZY and showed a good detection limit of 0.009 µM with a sensitivity of 6.77 µA/µM.cm.
阿奇霉素（AZY）是一种众所周知的首选抗生素，人类会以高浓度使用。然而，AZY 抗生素的副作用可能会对人类和环境造成一些严重和重大的损害。因此，需要开发有效的、灵敏的传感器来监测 AZY 的准确浓度。在过去的十年中，基于电化学的传感器因其高灵敏度、选择性、成本效益、快速响应、快速检测响应、简单的制造和工作原理而受到科学界的极大关注。值得一提的是，电化学传感器依赖于电极修饰剂的性质。因此，在设计和开发高效、稳健的电化学传感器时，选择电极材料非常重要。在这项研究中，我们通过利用二硫化钼/碳化钛铝（MoS@TiAlC）复合材料作为电极材料来制备 AZY 传感器。MoS@TiAlC 复合材料是通过简单的超声处理过程合成的。采用粉末 X 射线衍射（XRD）方法对合成的 MoS@TiAlC 复合材料进行了表征，以检查 MoS@TiAlC 复合材料的相纯度和形成。采用扫描电子显微镜（SEM）研究了制备的 MoS@TiAlC 复合材料的表面形貌特征，而采用能谱（EDAX）来确定制备的 MoS@TiAlC 复合材料的元素组成。用制备的 MoS@TiAlC 复合材料修饰玻碳（GC）电极，并将其用作 AZY 传感器。采用线性扫描伏安法研究了 MoS@TiAlC 复合材料修饰 GC 电极的传感性能。该传感器在测定 AZY 时表现出优异的性能，检测限低至 0.009 µM，灵敏度为 6.77 µA/µM.cm。
