Zai Muhammad Jawad, Cheesman Matthew James, Cock Ian Edwin
Centre for Planetary Health and Food Security, Griffith University, Brisbane, QLD 4111, Australia.
School of Environment and Science, Griffith University, Brisbane, QLD 4111, Australia.
Antibiotics (Basel). 2023 Nov 20;12(11):1643. doi: 10.3390/antibiotics12111643.
A. Cunn. Ex Benth. (genus: , family: Combretaceae) is native to Australia. spp. have traditionally been used to treat various ailments, including bacterial infections. Solvents of varying polarity were used to extract compounds from leaves of this species, and the extracts were tested against a panel of bacteria, including antibiotic-resistant strains. The methanolic and water extracts showed substantial inhibitory activity against several bacteria, including antibiotic-resistant strains in both disc diffusion and liquid dilution assays. Combining these extracts with selected conventional antibiotics enhanced the inhibition of bacterial growth for some combinations, while others showed no significant interaction. In total, two synergistic, twenty-five additive, twenty-three non-interactive and one antagonistic interaction were observed. The methanolic and ethyl acetate plant extracts were found to be non-toxic in nauplii toxicity assays. A liquid chromatography-mass spectrometry metabolomics analysis identified several flavonoid compounds, including miquelianin, trifolin and orientin, which might contribute to the observed activities. The potential modes of these active extracts are further discussed in this study.
A. Cunn. Ex Benth.（属： ，科：使君子科）原产于澳大利亚。该属植物传统上被用于治疗各种疾病，包括细菌感染。使用不同极性的溶剂从该物种的叶子中提取化合物，并针对一组细菌（包括抗生素耐药菌株）对提取物进行测试。甲醇提取物和水提取物在纸片扩散法和液体稀释法中均对几种细菌（包括抗生素耐药菌株）表现出显著的抑制活性。将这些提取物与选定的传统抗生素联合使用，对于某些组合增强了对细菌生长的抑制作用，而其他组合则未显示出显著的相互作用。总共观察到两种协同相互作用、二十五种相加相互作用、二十三种非相互作用和一种拮抗相互作用。在无节幼体毒性试验中发现甲醇提取物和乙酸乙酯植物提取物无毒。液相色谱 - 质谱代谢组学分析鉴定出几种黄酮类化合物，包括异槲皮苷、三叶豆苷和东方蓼黄素，它们可能是观察到的活性的原因。本研究进一步讨论了这些活性提取物的潜在作用方式。
