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载有磺胺嘧啶银的生物膜用于烧伤愈合的制剂及其体内评价

Formulation and In Vivo Evaluation of Biofilm Loaded with Silver Sulfadiazine for Burn Healing.

作者信息

Alshora Doaa, Ashri Lubna, Alfaraj Rihaf, Alhusaini Ahlam, Mohammad Raeesa, Alanaze Nawal, Ibrahim Mohamed, Badran Mohamed M, Bekhit Mounir, Alsaif Shaikha, Alagili Modhi, Ali Rehab A, Jreebi Adel

机构信息

Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 22452, Riyadh 11459, Saudi Arabia.

Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 22452, Riyadh 11459, Saudi Arabia.

出版信息

Gels. 2023 Oct 29;9(11):855. doi: 10.3390/gels9110855.

DOI:10.3390/gels9110855
PMID:37998947
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10670614/
Abstract

Infected burned skin is a life-threatening condition, which may lead to sepsis. The aims of this work are to formulate a biofilm composed of silver sulfadiazine (SSD), chitosan (CS), and sodium alginate (SA), and to evaluate its wound-healing effectiveness. A full factorial design was used to formulate different matrix formulations. The prepared biofilm was tested for physicochemical, and in vitro release. The optimized formulation is composed of 0.833% of CS and 0.75% of SA. The release of SSD almost reached 100% after 6 h. The mechanical properties of the optimized formula were reasonable. The antibacterial activity for the optimized biofilm was significantly higher than that of blank biofilm, which is composed of CS and SA, = 1.53922 × 10. Moreover, the in vivo study showed a 75% reduction in wound width when using the formulated SSD biofilm compared to standard marketed cream (57%) and the untreated group (0%).

摘要

感染的烧伤皮肤是一种危及生命的状况，可能导致败血症。这项工作的目的是制备一种由磺胺嘧啶银（SSD）、壳聚糖（CS）和海藻酸钠（SA）组成的生物膜，并评估其伤口愈合效果。采用全因子设计来制备不同的基质配方。对制备的生物膜进行了物理化学性质和体外释放测试。优化后的配方由0.833%的CS和0.75%的SA组成。SSD在6小时后释放率几乎达到100%。优化配方的机械性能良好。优化后的生物膜的抗菌活性显著高于由CS和SA组成的空白生物膜，= 1.53922 × 10。此外，体内研究表明，与市售标准乳膏（57%）和未治疗组（0%）相比，使用制备的SSD生物膜时伤口宽度减少了75%。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6f6/10670614/1f46e41de2a7/gels-09-00855-g011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6f6/10670614/1f46e41de2a7/gels-09-00855-g011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6f6/10670614/06c8d2bcca80/gels-09-00855-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6f6/10670614/0c938dc8ed9d/gels-09-00855-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6f6/10670614/2cdd47b715e2/gels-09-00855-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6f6/10670614/a7daee456478/gels-09-00855-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6f6/10670614/950e5a908f63/gels-09-00855-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6f6/10670614/1f46e41de2a7/gels-09-00855-g011.jpg

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