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BIRC5 是与肿瘤免疫细胞浸润相关的预后生物标志物。

BIRC5 is a prognostic biomarker associated with tumor immune cell infiltration.

机构信息

Department of Hepato-Biliary-Pancreatic Surgery, Jiujiang First People's Hospital, Jiujiang, 332000, China.

Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, 330006, China.

出版信息

Sci Rep. 2021 Jan 11;11(1):390. doi: 10.1038/s41598-020-79736-7.

DOI:10.1038/s41598-020-79736-7
PMID:33431968
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7801710/
Abstract

BIRC5 is an immune-related gene that inhibits apoptosis and promotes cell proliferation. It is highly expressed in most tumors and leads to poor prognosis in cancer patients. This study aimed to analyze the relationship between the expression level of BIRC5 in different tumors and patient prognosis, clinical parameters, and its role in tumor immunity. Genes co-expressed with BIRC5 were analyzed, and functional enrichment analysis was performed. The relationship between BIRC5 expression and the immune and stromal scores of tumors in pan-cancer patients and the infiltration level of 22 tumor-infiltrating lymphocytes (TILs) was analyzed. The correlation of BIRC5 with immune checkpoints was conducted. Functional enrichment analysis showed that genes co-expressed with BIRC5 were significantly associated with the mitotic cell cycle, APC/C-mediated degradation of cell cycle proteins, mitotic metaphase, and anaphase pathways. Besides, the high expression of BIRC5 was significantly correlated with the expression levels of various DNA methyltransferases, indicating that BIRC5 regulates DNA methylation. We also found that BIRC5 was significantly correlated with multiple immune cells infiltrates in a variety of tumors. This study lays the foundation for future research on how BIRC5 modulates tumor immune cells, which may lead to the development of more effective targeted tumor immunotherapies.

摘要

BIRC5 是一个与免疫相关的基因，它能抑制细胞凋亡并促进细胞增殖。它在大多数肿瘤中高表达，导致癌症患者预后不良。本研究旨在分析不同肿瘤中 BIRC5 的表达水平与患者预后、临床参数的关系及其在肿瘤免疫中的作用。分析与 BIRC5 共表达的基因，并进行功能富集分析。分析 BIRC5 表达与泛癌患者肿瘤免疫和基质评分以及 22 种肿瘤浸润淋巴细胞（TILs）浸润水平的关系。分析 BIRC5 与免疫检查点的相关性。功能富集分析表明，与 BIRC5 共表达的基因与有丝分裂细胞周期、APC/C 介导的细胞周期蛋白降解、有丝分裂中期和后期途径显著相关。此外，BIRC5 的高表达与各种 DNA 甲基转移酶的表达水平显著相关，表明 BIRC5 调节 DNA 甲基化。我们还发现 BIRC5 与多种肿瘤中多种免疫细胞浸润显著相关。这项研究为未来研究 BIRC5 如何调节肿瘤免疫细胞奠定了基础，这可能会导致开发更有效的靶向肿瘤免疫疗法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07fc/7801710/d7cb25d467b7/41598_2020_79736_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07fc/7801710/067bf1a05f0a/41598_2020_79736_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07fc/7801710/dcb279e1f935/41598_2020_79736_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07fc/7801710/70279bdbe6ef/41598_2020_79736_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07fc/7801710/0a5113473708/41598_2020_79736_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07fc/7801710/65cfbad470b2/41598_2020_79736_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07fc/7801710/d7cb25d467b7/41598_2020_79736_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07fc/7801710/067bf1a05f0a/41598_2020_79736_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07fc/7801710/dcb279e1f935/41598_2020_79736_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07fc/7801710/70279bdbe6ef/41598_2020_79736_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07fc/7801710/0a5113473708/41598_2020_79736_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07fc/7801710/65cfbad470b2/41598_2020_79736_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07fc/7801710/d7cb25d467b7/41598_2020_79736_Fig6_HTML.jpg

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