School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China.
Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou 510260, China.
Int J Mol Sci. 2023 Nov 8;24(22):16096. doi: 10.3390/ijms242216096.
Four new sorbicillinoids, named trichodermolide E (), trichosorbicillin J (), bisorbicillinolide B (), and demethylsorbiquinol (), together with eight known compounds (, -), were isolated from the cultures of the mangrove-derived fungus BGRg-3. The structures of the new compounds were determined by analyzing their detailed spectroscopic data, while the absolute configurations were further determined through electronic circular dichroism calculations. Snatzke's method was additionally used to determine the absolute configurations of the diol moiety in . In a bioassay, compounds and performed greater inhibitory activities on interleukin-6 and interleukin-1β than the positive control (dexamethasone) at the concentration of 25 μM. Meanwhile, compounds and showed potent effects with stronger inhibition than dexamethasone on IL-1β at the same concentration.
从红树林来源的真菌 BGRg-3 的培养物中分离得到了四个新的索比菌素类化合物，分别命名为 Trichodermolide E ()、Trichosorbicillin J ()、Bisorbicillinolide B () 和 Demethylsorbiquinol ()，以及八个已知化合物 (, -)。通过分析其详细的光谱数据确定了新化合物的结构，而绝对构型则通过电子圆二色性计算进一步确定。此外，Snatzke 法还用于确定化合物中二醇部分的绝对构型。在生物测定中，化合物和在 25 μM 的浓度下对白细胞介素-6 和白细胞介素-1β 的抑制活性大于阳性对照（地塞米松）。同时，化合物和在相同浓度下对 IL-1β 的抑制作用强于地塞米松，表现出更强的效果。
