Mono- and Dimeric Sorbicillinoid Inhibitors Targeting IL-6 and IL-1β from the Mangrove-Derived Fungus BGRg-3.

Four new sorbicillinoids, named trichodermolide E (), trichosorbicillin J (), bisorbicillinolide B (), and demethylsorbiquinol (), together with eight known compounds (, -), were isolated from the cultures of the mangrove-derived fungus BGRg-3. The structures of the new compounds were determined by analyzing their detailed spectroscopic data, while the absolute configurations were further determined through electronic circular dichroism calculations. Snatzke's method was additionally used to determine the absolute configurations of the diol moiety in . In a bioassay, compounds and performed greater inhibitory activities on interleukin-6 and interleukin-1β than the positive control (dexamethasone) at the concentration of 25 μM. Meanwhile, compounds and showed potent effects with stronger inhibition than dexamethasone on IL-1β at the same concentration.