Hou Xuwen, Zhang Xuping, Xue Mengyao, Zhao Zhitong, Zhang Huizhen, Xu Dan, Lai Daowan, Zhou Ligang
State Key Laboratory of Agrobiotechnology, Department of Plant Pathology, College of Plant Protection, China Agricultural University, Beijing 100193, China.
J Fungi (Basel). 2022 Jan 7;8(1):62. doi: 10.3390/jof8010062.
Sorbicillinoids are a family of hexaketide metabolites with a characteristic sorbyl side chain residue. Sixty-nine sorbicillinoids from fungi, newly identified from 2016 to 2021, are summarized in this review, including their structures and bioactivities. They are classified into monomeric, dimeric, trimeric, and hybrid sorbicillinoids according to their basic structural features, with the main groups comprising both monomeric and dimeric sorbicillinoids. Some of the identified sorbicillinoids have special structures such as ustilobisorbicillinol A, and sorbicillasins A and B. The majority of sorbicillinoids have been reported from fungi genera such as , , , and , with some sorbicillinoids exhibiting cytotoxic, antimicrobial, anti-inflammatory, phytotoxic, and α-glucosidase inhibitory activities. In recent years, marine-derived, extremophilic, plant endophytic, and phytopathogenic fungi have emerged as important resources for diverse sorbicillinoids with unique skeletons. The recently revealed biological activities of sorbicillinoids discovered before 2016 are also described in this review.
聚酮类化合物是一类具有特征性山梨醇侧链残基的六酮类代谢产物。本文综述了2016年至2021年间新鉴定出的69种来自真菌的聚酮类化合物，包括它们的结构和生物活性。根据其基本结构特征，它们被分为单体、二聚体、三聚体和杂合聚酮类化合物，主要类别包括单体和二聚体聚酮类化合物。一些已鉴定的聚酮类化合物具有特殊结构，如腐马比色菌素A以及山梨色菌素A和B。大多数聚酮类化合物已从曲霉属、青霉属、镰刀菌属和链格孢属等真菌中报道，一些聚酮类化合物具有细胞毒性、抗菌、抗炎、植物毒性和α-葡萄糖苷酶抑制活性。近年来，海洋来源、极端嗜热、植物内生和植物致病真菌已成为具有独特骨架多样聚酮类化合物的重要资源。本文还描述了2016年之前发现的聚酮类化合物最近揭示的生物活性。
