RDC Clinical, Brisbane, QLD, Australia.
School of Medicine, University of Sydney, Sydney, NSW, Australia.
J Hum Nutr Diet. 2022 Jun;35(3):583-589. doi: 10.1111/jhn.12936. Epub 2021 Aug 9.
The present study examined the effect of a herbal supplement containing a Gynostemma pentaphyllum (Gpp) extract (ActivAMP®) with respect to improving body composition in overweight males and females.
One-hundred and seventeen men and women aged over 18 years completed 16 weeks of daily supplementation with either Gpp or a placebo. Participants underwent dual-energy X-rays to assess body composition (fat mass, lean mass and mass distribution), as well as anthropometric measures (weight, height, hip and waist circumference), in addition to blood tests to assess inflammatory and safety markers.
Following 16 weeks of treatment, the Gpp group had a significant reduction in total body weight, body mass index, total fat mass and gynoid fat mass compared to the placebo group. Blood measures showed plasma triglyceride, alanine aminotransferase and tumour necrosis factor-α to be statistically different between groups at week 16. Subgroup analysis of gender for fat distribution showed males in the Gpp group had a significant reduction in visceral fat compared to males in the placebo group and females in the Gpp group had a significant reduction in gynoid fat compared to the placebo group.
Gpp was capable of altering fat mass and fat distribution in overweight and obese males and females compared to a placebo.
本研究考察了一种含有绞股蓝（Gpp）提取物（ActivAMP®）的草药补充剂对改善超重男性和女性身体成分的影响。
117 名年龄在 18 岁以上的男性和女性完成了为期 16 周的每日补充 Gpp 或安慰剂的试验。参与者接受了双能 X 射线检查，以评估身体成分（脂肪量、瘦体重和体重分布）以及人体测量学指标（体重、身高、臀围和腰围），此外还进行了血液检查以评估炎症和安全性标志物。
经过 16 周的治疗，与安慰剂组相比，Gpp 组的总体重、体重指数、总脂肪量和女性型脂肪量显著减少。血液检查结果显示，第 16 周时，血浆甘油三酯、丙氨酸氨基转移酶和肿瘤坏死因子-α在组间存在统计学差异。脂肪分布的性别亚组分析显示，与安慰剂组相比，Gpp 组男性的内脏脂肪显著减少，而 Gpp 组女性的女性型脂肪显著减少。
与安慰剂相比，Gpp 能够改变超重和肥胖男性和女性的脂肪量和脂肪分布。
