School of Pharmacy, Southwest Medical University, Luzhou, 646000, China.
School of Life Sciences, Jiangsu Normal University, Xuzhou, 221116, Jiangsu, China.
Plant Foods Hum Nutr. 2024 Mar;79(1):73-82. doi: 10.1007/s11130-023-01123-0. Epub 2023 Nov 25.
Fruits of Syzygium jambos (L.) are recognized as a "food", exhibiting significant antidiabetic activities. However, the α-glucosidase inhibition of the components from Syzygium jambos (L.) have not yet been investigated. In this study, a total of 14 compounds were isolated from Syzygium jambos (L.) Alston, eight of which showed significant inhibitory effects on α-glucosidase, with IC values in the range of 0.011-0.665 mM. Notably, compounds 1-3 (IC: 0.013, 0.011 and 0.030 mM, respectively) exhibited much stronger activity than acarbose (IC: 2.329 ± 0.109 mM). The enzyme kinetics study indicated that compound 1 was an uncompetitive inhibitor, and compounds 2-8 were mixed-type inhibitors. Moreover, the interactions between compounds and α-glucosidase were investigated by molecular docking, which further revealed that the number of olefin double bonds and 2-COOH of heptadeca-phenols had a notable effect on the α-glucosidase inhibitory activity. This study demonstrated that Syzygium jambos (L.) fruit might serve as a functional food for the prevention of diabetes mellitus.
杨桃的果实被认为是一种“食品”，具有显著的抗糖尿病活性。然而，杨桃（Syzygium jambos（L.））成分的α-葡萄糖苷酶抑制作用尚未得到研究。在本研究中，从杨桃（Syzygium jambos（L.）Alston）中分离得到了 14 种化合物，其中 8 种对α-葡萄糖苷酶表现出显著的抑制作用，IC 值在 0.011-0.665 mM 范围内。值得注意的是，化合物 1-3（IC：0.013、0.011 和 0.030 mM，分别）的活性比阿卡波糖（IC：2.329 ± 0.109 mM）强得多。酶动力学研究表明，化合物 1 是一种非竞争性抑制剂，化合物 2-8 是混合型抑制剂。此外，通过分子对接研究了化合物与α-葡萄糖苷酶之间的相互作用，进一步表明，十七烷酚中烯烃双键和 2-COOH 的数量对α-葡萄糖苷酶抑制活性有显著影响。本研究表明，杨桃果实可能可作为预防糖尿病的功能性食品。
