Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt.
Center of Drug Discovery Research and Development, Ain Shams University, Cairo 11566, Egypt.
Molecules. 2021 Nov 19;26(22):6984. doi: 10.3390/molecules26226984.
(Pomposia) is a well-known aromatic plant belonging to the family Myrtaceae, and has been reported for its various traditional and pharmacological potentials, such as its antioxidant, antimicrobial, anti-inflammatory, and antidiarrheal properties. The chemical composition of the leaf essential oil via gas chromatography-mass spectrometry (GC/MS) analysis revealed the identification of fifty-three compounds representing about 91.22% of the total oil. The identified oil was predominated by -pinene (21.09%), followed by -(E)-ocimene (11.80%), D-limonene (8.08%), -pinene (7.33%), and -terpineol (5.38%). The tested oil revealed a moderate cytotoxic effect against human liver cancer cells (HepG2) with an IC value of 38.15 ± 2.09 µg/mL. In addition, it effectively inhibited acetylcholinesterase with an IC value of 32.9 ± 2.1 µg/mL. Furthermore, it showed inhibitory properties against α-amylase and α-glucosidase with IC values of 57.80 ± 3.30 and 274.03 ± 12.37 µg/mL, respectively. The molecular docking studies revealed that ()--caryophyllene, one of the major compounds, achieved the best docking scores of -6.75, -5.61, and -7.75 for acetylcholinesterase, α-amylase, and α-glucosidase, respectively. Thus, it is concluded that oil should be considered as a food supplement for the elderly to enhance memory performance and for diabetic patients to control blood glucose.
（香桃木）是桃金娘科的一种芳香植物，具有多种传统和药理学潜力，如抗氧化、抗菌、抗炎和抗腹泻特性。通过气相色谱-质谱联用（GC/MS）分析对其叶精油的化学成分进行了研究，鉴定了 53 种化合物，占总油的 91.22%左右。鉴定出的精油以 -蒎烯（21.09%）为主，其次为 -（E）-罗勒烯（11.80%）、D-柠檬烯（8.08%）、-蒎烯（7.33%）和 -松油醇（5.38%）。该油对人肝癌细胞（HepG2）具有中等细胞毒性，IC 值为 38.15 ± 2.09 µg/mL。此外，它还能有效抑制乙酰胆碱酯酶，IC 值为 32.9 ± 2.1 µg/mL。此外，它对α-淀粉酶和α-葡萄糖苷酶的抑制作用分别为 IC 值为 57.80 ± 3.30 和 274.03 ± 12.37 µg/mL。分子对接研究表明，（）-石竹烯是主要化合物之一，在乙酰胆碱酯酶、α-淀粉酶和α-葡萄糖苷酶上的对接评分分别达到了-6.75、-5.61 和-7.75。因此，可以得出结论，该精油可作为老年人的膳食补充剂，以提高记忆力，也可作为糖尿病患者的辅助药物，以控制血糖。
