Wei Y Q, Lyu L H, Li M
School of Laboratory Medicine, Bengbu Medical College, Bengbu 233030, China Department of Laboratory Medicine, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230032, China.
Department of Laboratory Medicine, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230032, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2023 Nov 6;57(11):1895-1900. doi: 10.3760/cma.j.cn112150-20230421-00312.
Eosinophils are important immune cells that contain eosinophilic particles and play a key role in allergic diseases such as asthma and helminth infections. An increasing number of studies have confirmed that eosinophils infiltrate a variety of tumor tissues, which can synthesize and secrete a large number of bioactive substances under certain circumstances, such as cytotoxic cationic proteins, cytokines, growth factors, chemokines, enzymes and so on, which may affect angiogenesis and matrix remodeling or change the tumor microenvironment, thereby affecting tumor progression. This review focused on the role of eosinophils in lung cancer and provided an outlook on the issues in clinical and basic research.
嗜酸性粒细胞是重要的免疫细胞，含有嗜酸性颗粒，在哮喘和蠕虫感染等过敏性疾病中起关键作用。越来越多的研究证实，嗜酸性粒细胞浸润多种肿瘤组织，在某些情况下可合成并分泌大量生物活性物质，如细胞毒性阳离子蛋白、细胞因子、生长因子、趋化因子、酶等，这些物质可能影响血管生成和基质重塑，或改变肿瘤微环境，从而影响肿瘤进展。本文综述聚焦于嗜酸性粒细胞在肺癌中的作用，并对临床和基础研究中的问题进行了展望。
