Ghafouri Seyed Ali, Ghaniei Abolfazl, Sadr Soheil, Amiri Amir Ali, Tavanaee Tamannaei Amir Ebrahim, Charbgoo Ali, Ghiassi Shakila, Dianat Behnoush
Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
Makian Dam Pars Science-Based Company, Tehran, Iran.
J Parasit Dis. 2023 Dec;47(4):820-828. doi: 10.1007/s12639-023-01627-1. Epub 2023 Sep 14.
Avian coccidiosis is considered among the infectious disease of high cost in the poultry industry. Herbal extracts are safe and reliable substitute anticoccidial drugs for chemical feed additives as they do not sequel to drug resistance and tissue remnants.
The current study aimed to assess the anticoccidial effect of an herbal complex of 3 plants (, , and ) in broiler chickens compared to toltrazuril anticoccidial.
This experiment used one hundred twenty broiler chickens and divided them into four equally numbered groups. All the groups, except group (D), were experimentally infected with mixed spp. (. , , and ) on day 14. Group (A) was treated with a herbal mixture, containing 75% with a minimum of 30% total tannin, 16% with a minimum of 0.02% artemisinin, and 9% with a minimum of 0.4% total phenol contents. Group (B) was treated with toltrazuril. Group (C) did not have any treatment. Group (D) was healthy all the experiment period as a negative control group. During a 42-day breeding period, the study examined clinical signs, weight gains, feed conversion ratio, lesions scoring, casualties, and the number of oocysts in different bird groups.
Group (D) showed the most significant weight gain, indicating the economic damage caused by coccidiosis. The best feed conversion ratio was observed in the unchallenged group, and coccidiosis negatively affected it in other groups. Clinical signs of dysentery, diarrhea, and lethargy were seen post-challenge but improved with treatment. Group (D) showed no losses; others had casualties and coccidiosis lesions. Lesion scores were lowest in the group (D), and the herbal mixture improved performance. The herbal mixture and toltrazuril reduced oocyst counts in feces earlier than the untreated group.
In conclusion, the anticoccidial activity of the mentioned herbal complex recommends its use as an alternative anticoccidial agent to chemotherapeutic drugs for controlling coccidiosis.
禽球虫病被认为是家禽业中成本高昂的传染病之一。草药提取物是安全可靠的化学饲料添加剂替代抗球虫药物，因为它们不会导致耐药性和组织残留。
本研究旨在评估三种植物（、和）的草药复合物与托曲珠利抗球虫药相比对肉鸡的抗球虫效果。
本实验使用120只肉鸡，将它们平均分为四组。除（D）组外，所有组在第14天通过混合种（、、和）进行实验性感染。（A）组用一种草药混合物治疗，该混合物含有75%的，总单宁含量至少为30%，16%的，青蒿素含量至少为0.02%，9%的，总酚含量至少为0.4%。（B）组用托曲珠利治疗。（C）组未进行任何治疗。（D）组在整个实验期间保持健康作为阴性对照组。在42天的饲养期内，该研究检查了不同鸡群的临床症状、体重增加、饲料转化率、病变评分、伤亡情况和卵囊数量。
（D）组体重增加最为显著，表明球虫病造成的经济损失。在未受感染的组中观察到最佳的饲料转化率，球虫病对其他组产生了负面影响。攻毒后出现了痢疾、腹泻和嗜睡等临床症状，但治疗后有所改善。（D）组没有损失；其他组有伤亡和球虫病病变。（D）组的病变评分最低，草药混合物改善了性能。草药混合物和托曲珠利比未治疗组更早地减少了粪便中的卵囊数量。
总之，上述草药复合物的抗球虫活性表明它可作为控制球虫病的化学治疗药物的替代抗球虫剂。
