瑞典农药施用者患恶性淋巴瘤的风险。
Risk of malignant lymphoma in Swedish pesticide appliers.
作者信息
Wiklund K, Dich J, Holm L E
机构信息
Department of Cancer Epidemiology, Karolinska Hospital and Institute, Stockholm, Sweden.
出版信息
Br J Cancer. 1987 Oct;56(4):505-8. doi: 10.1038/bjc.1987.234.
The risk of Hodgkin's disease (HD) and non-Hodgkin lymphoma (NHL) was studied in a cohort of 20,245 Swedish pesticide appliers, who had the licence issued between 1965 and 1976. In this cohort 72% were estimated to have been exposed to phenoxy acid herbicides. The cohort was followed-up in the Swedish Cancer Register from date of licence until Dec. 31, 1982 or until death if prior to that date. The mean follow-up time was 12.2 years. A total of 11 cases with HD and 21 cases with NHL were observed compared to 9.1 and 20.8 expected. The relative risks and the 95% confidence intervals were for HD 1.20 (0.60-2.16) and for NHL 1.01 (0.63-1.54). The relative risk rose, but not to statistical significance however, with increased time since licence for both diagnoses.
在一组20245名瑞典农药施用者中研究了霍奇金病（HD）和非霍奇金淋巴瘤（NHL）的风险，这些人持有1965年至1976年间颁发的许可证。在这组人群中，估计72%的人接触过苯氧基酸除草剂。该队列从发放许可证之日起在瑞典癌症登记处进行随访，直至1982年12月31日，若在此日期之前死亡则随访至死亡。平均随访时间为12.2年。共观察到11例HD病例和21例NHL病例，而预期分别为9.1例和20.8例。HD的相对风险和95%置信区间为1.20（0.60 - 2.16），NHL为1.01（0.63 - 1.54）。两种诊断的相对风险均随发放许可证后的时间增加而上升，但未达到统计学显著性。
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