Department of Physical Activity Research, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan.
Laboratory of Gut Microbiome for Health, Microbial Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
Sci Rep. 2023 Nov 27;13(1):20841. doi: 10.1038/s41598-023-47442-9.
Escherichia coli harboring polyketide synthase (pks E. coli) has been suggested to contribute to colorectal cancer development. Physical activity is strongly associated with lower colorectal cancer risks, but its effects on pks E. coli remain unclear. The aim of this study was to investigate the association between pks E. coli prevalence and physical activity. A cross-sectional study was conducted on 222 Japanese adults (27-79-years-old, 73.9% female). Triaxial accelerometers were used to measure light-intensity physical activity, moderate-to-vigorous intensity physical activity, the physical activity level, step-count, and time spent inactive. Fecal samples collected from participants were used to determine the prevalence of pks E. coli. Multivariate logistic regression analysis and restricted cubic spline curves were used to examine the association between pks E. coli prevalence and physical activity. The prevalence of pks E. coli was 26.6% (59/222 participants). The adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the highest tertile with reference to the lowest tertile of physical activity variables were as follows: light-intensity physical activity (OR 0.63; 95% CI 0.26-1.5), moderate-to-vigorous intensity physical activity (OR 0.85; 95% CI 0.39-1.87), physical activity level (OR 0.69; 95% CI 0.32-1.51), step-count (OR 0.92; 95% CI 0.42-2.00) and time spent inactive (OR 1.30; 95% CI 0.58-2.93). No significant dose-response relationship was found between all physical activity variables and pks E. coli prevalence. Our findings did not suggest that physical activity has beneficial effects on the prevalence of pks E. coli. Longitudinal studies targeting a large population are needed to clarify this association.
产聚酮化合物大肠杆菌（pks E. coli）与结直肠癌的发展有关。身体活动与结直肠癌风险降低密切相关，但它对 pks E. coli 的影响尚不清楚。本研究旨在探讨 pks E. coli 流行率与身体活动之间的关系。对 222 名日本成年人（27-79 岁，73.9%为女性）进行了横断面研究。使用三轴加速度计测量低强度体力活动、中高强度体力活动、体力活动水平、步数和不活动时间。收集参与者的粪便样本，以确定 pks E. coli 的流行率。使用多变量逻辑回归分析和限制立方样条曲线来检查 pks E. coli 流行率与身体活动之间的关系。pks E. coli 的流行率为 26.6%（222 名参与者中有 59 名）。以体力活动变量的最低三分位为参照，最高三分位的调整后比值比（OR）和 95%置信区间（CI）如下：低强度体力活动（OR 0.63；95%CI 0.26-1.5）、中高强度体力活动（OR 0.85；95%CI 0.39-1.87）、体力活动水平（OR 0.69；95%CI 0.32-1.51）、步数（OR 0.92；95%CI 0.42-2.00）和不活动时间（OR 1.30；95%CI 0.58-2.93）。所有体力活动变量与 pks E. coli 流行率之间未发现显著的剂量-反应关系。我们的研究结果表明，身体活动对 pks E. coli 的流行率没有有益的影响。需要针对较大人群的纵向研究来阐明这种关联。
